Results 11 to 20 of about 921,496 (243)

Mitochondria-Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation. [PDF]

Adv Sci (Weinh)
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Su Y, Gong Z, Mu J, Huang L, Yang P, Zhang C, Zhao L, Yang L, Deng J, Liao X.   +9 more
europepmc   +2 more sources

Extreme intraspecific divergence in mitochondrial haplotypes makes the threespine stickleback fish an emerging evolutionary mutant model for mito-nuclear interactions

Frontiers in Genetics, 2022
Mitochondrial DNA is primarily maternally inherited in most animals and evolves about 10 times faster than biparentally inherited nuclear DNA. Mitochondrial dysfunction (mt-dys) arises when interactions between the co-evolving mitochondrial and nuclear ...
Emily A. Beck, Emily A. Beck, Susan Bassham, William A. Cresko, William A. Cresko   +4 more
doaj   +1 more source

Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy

Advanced Science, 2023
Azacitidine (AZA) is a DNA methyltransferase inhibitor and epigenetic modulator that can be an effective agent in combination with chemotherapy for patients with high‐risk acute myeloid leukemia (AML).
Guanghao Liang, Linchen Wang, Qiancheng You, Kirk Cahill, Chuanyuan Chen, Wei Zhang, Noreen Fulton, Wendy Stock, Olatoyosi Odenike, Chuan He, Dali Han   +10 more
doaj   +1 more source

The complete mitochondrial genomes of Parabotia kiangsiensis (Cypriniformes: Botiidae)

Mitochondrial DNA. Part B. Resources, 2020
Parabotia kiangsiensis is an endemic species of genus Parabotia in China. In this study, we sequenced the complete mito-genome of P. kiangsiensis. The genome is 16,592 base pair (bp) in length, encoding 13 protein-coding genes, 22 tRNA genes, 2 rRNA ...
Qin Ma, Tonglin Zhang, Lin Chen, Qiongying Tang   +3 more
doaj   +1 more source

Distinguishing between incomplete lineage sorting and genomic introgressions: complete fixation of allospecific mitochondrial DNA in a sexually reproducing fish (Cobitis; Teleostei), despite clonal reproduction of hybrids. [PDF]

PLoS ONE, 2014
Distinguishing between hybrid introgression and incomplete lineage sorting causing incongruence among gene trees in that they exhibit topological differences requires application of statistical approaches that are based on biologically relevant models ...
Lukas Choleva, Zuzana Musilova, Alena Kohoutova-Sediva, Jan Paces, Petr Rab, Karel Janko   +5 more
doaj   +1 more source

Identification of Mitochondrial-Related Prognostic Biomarkers Associated With Primary Bile Acid Biosynthesis and Tumor Microenvironment of Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is one of the leading causes of tumor-associated deaths worldwide. Despite great progress in early diagnosis and multidisciplinary tumor management, the long-term prognosis of HCC remains poor.
Tao Zhang, Yingli Nie, Jian Gu, Kailin Cai, Xiangdong Chen, Huili Li, Jiliang Wang   +6 more
doaj   +1 more source

Pig genome sequence - analysis and publication strategy [PDF]

, 2010
Background The pig genome is being sequenced and characterised under the auspices of the Swine Genome Sequencing Consortium. The sequencing strategy followed a hybrid approach combining hierarchical shotgun sequencing of BAC clones and whole genome ...
Fredholm, M., Harlizius Barbara, Martien A M Groenen, Bolund, Lars, Rothschild Max F, Lee Kyung-Tai, Jane Rogers, Barbara Harlizius, Denis Milan, Groenen, M.A.M., Lee, Kyung-Tai, ?, ?, Uenishi, Hirohide, Jun Wang, Uenishi Hirohide, Churcher, C., Harlizius, Barbara, Lars Bolund, Lawrence B Schook, Alan L Archibald, Archibald Alan L, Fredholm, Merete, Groenen, Martien A. M., Schook, Lawrence B., Harlizius, B., Fredholm Merete, Archibald, A.L., The Swine Genome Sequencing Consortium,, Milan Denis, Bolund Lars, Groenen, Martien A.M., Rogers Jane, Wang Jun, Swine Genome Sequencing Consortium, Hirohide Uenishi, Groenen Martien AM, Rothschild, Max F., Bolund, L., Milan, Denis, Archibald, Alan L., Wang, Jun, Merete Fredholm, Kyung-Tai Lee, The Swine Genome Sequencing Consortium, -, Carol Churcher, Rogers, Jane, Churcher, Carol, Max F Rothschild, Schook Lawrence B, Churcher Carol   +49 more
core   +1 more source

Mitochondrial-nuclear epistasis underlying phenotypic variation in breast cancer pathology

Scientific Reports, 2022
The interplay between genes harboring single nucleotide polymorphisms (SNPs) is vital to better understand underlying contributions to the etiology of breast cancer.
Pierre R. Bushel, James Ward, Adam Burkholder, Jianying Li, Benedict Anchang   +4 more
doaj   +1 more source

Isolation and characterization of the mitochondrial genome of Gymnodraco acuticeps (Perciformes: Bathydraconidae) with phylogenetic consideration

Mitochondrial DNA. Part B. Resources, 2017
Gymnodraco acuticepsis is an Antarctic fish living in the Southern Ocean. Until now, studies on G. acuticeps are still limited. As an Antarctic fish, obtaining and characterization of the mitochondrial genome of G.
Wei Song, Lingzhi Li, Hongliang Huang, Fenfang Chen, Ming Zhao, Keji Jiang, Fengying Zhang, Chunyan Ma, Xuezhong Chen, Lingbo Ma   +9 more
doaj   +1 more source

The complete mitochondrial genome of Neopagetopsis ionah (Channichthyidae, neopagetopsis) with phylogenetic consideration

Mitochondrial DNA. Part B. Resources, 2018
In this study, the complete mitochondrial genome of Neopagetopsis ionah was obtained, which was 17,634 bp including two ribosomal RNAs, 13 protein-coding genes, 22 transfer RNAs, and a non-coding control region. In 13 protein-coding genes, there types of
Chengde Sang, Shuzhang Liang, Wei Song, Hongliang Huang, Keji Jiang, Xuezhong Chen   +5 more
doaj   +1 more source