Results 181 to 190 of about 921,496 (243)

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming. [PDF]

Bioact Mater
Li H, Zhang Y, Jian Y, Fang F, Ouyang W, Zhuang D, Ju W, Gao R, Gao Y, Kang S, Kong P, Li Y, Pan X, Wang W, Feng Z.   +14 more
europepmc   +1 more source

Hepatocyte Growth Hormone Receptor Ablation Is Associated With Aging Phenotypes and Hepatic Mitochondrial Dysfunction

Aging Cell, Volume 25, Issue 10, October 2026.
Hepatocyte‐specific GHR ablation is associated with hepatic and age‐related pathologies, triggering adipose‐liver crosstalk via elevated circulating GH and subsequent CD36‐dependent hepatic steatosis. This loss impairs STAT5b phosphorylation and enhances PPARγ nuclear activation, upregulating Pdk4 and Cd36 to drive mitochondrial dysfunction and ectopic
Kangkang Yang, Yuli Jian, Fusheng Pang, Ming Ying, Qian Yang, Nian Liu, Shujing Wang, Yingjie Wu   +7 more
wiley   +1 more source

EZmito2: a tool suite for mitochondrial genome dataset preparation, population genetics, and visualization. [PDF]

Mol Biol Evol
Cucini C, Pons J, Funari R, Carapelli A, Frati F, Nardi F.   +5 more
europepmc   +1 more source

ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley   +1 more source

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis. [PDF]

Nat Commun
Sarrazin L, Rosenthal MR, Kloehn J, Ziesmann T, Schmitz Y, Sandtmann AL, Domènech-Eres R, Scholz-Höhn K, Boulet C, Distler U, Goldberg DE, Matz JM.   +11 more
europepmc   +1 more source

Elucidating the Role of SET as a Key Contributor to Neurodevelopmental Disability Within the 9q34.11 Deletion Syndrome Interval

Clinical Genetics, Volume 110, Issue 4, Page 438-448, October 2026.
This study reports a female proband with a de novo 9q34.11 deletion affecting SET, who underwent a 28‐year diagnostic odyssey after an atypical Rett syndrome clinical diagnosis. Genomic and proteomics analyses confirmed SET haploinsufficiency, refining the critical 9q34.11 region, and supporting speech therapy benefits in improving meaningful ...
Angelo Condell, Elaine Zhang, Tim Sikora, Sean Massey, Nicole J. Van Bergen, Min Wang, Cas Simons, Katrina M. Bell, Daniella H. Hock, David A. Stroud, David Francis, Wendy A. Gold, Martin B. Delatycki, John Christodoulou, Simranpreet Kaur   +14 more
wiley   +1 more source

Mitochondrial translation termination, recycling, reinitiation, and rescue for in-frame and out-of-frame contexts. [PDF]

Nat Commun
Wakigawa T, Mito M, Fang Q, Itoh Y, Shinkai Y, Iwasaki S.   +5 more
europepmc   +1 more source

Lipid Accumulation Promotes Tumorigenic Behaviour of Colorectal Cancer Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Obesity and hyperlipidemia are risk factors for the development and progression of different types of cancer including colorectal cancer (CRC). The underlying mechanisms are only incompletely understood. The aim of this study was to assess the impact of hyperlipidemic conditions on tumorigenic behaviour of CRC cells and the effect of obesity ...
Tatjana Itzenhäuser, Fulya Suzan Schildt, Seraphine Jochem, Judith Sommer, Michael Stürzl, Elisabeth Naschberger, Anja Katrin Boßerhoff, Claus Hellerbrand   +7 more
wiley   +1 more source

The complete mitochondrial genome of <i>Ramulus bifarius</i> (Phasmida: Phasmatidae; Clitumninae). [PDF]

Microbiol Resour Announc
Han R, Bian X, Zhang B.
europepmc   +1 more source