Results 111 to 120 of about 62,676 (260)

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Del mito creacionista al mito futurista

Calle 14: Revista de Investigación en el Campo del Arte, 2011
La primera foto tomada a la Tierra desde el espacio, en 1946, es uno de los signos de la reprogramación mitológica que está afectando la percepción actual de las ciencias y las artes. Esta reprogramación opone a Dios como artífice y al artista como dios creador: un superhumano tecnólogo y un artista administrador de la Tierra.
openaire   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

Radiomics‐based ultrasOund Model for differentiating Uterine Sarcomas from leiomyomas (ROMUS): a retrospective pilot Multicenter Italian Trials in Ovarian Cancer (MITO) study

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To develop machine‐learning models that incorporate clinical information and radiomics features extracted from ultrasound images to distinguish uterine sarcomas from leiomyomas. Methods This retrospective, multicenter, pilot case–control study included 200 patients (100 with a uterine sarcoma and 100 with a usual‐type leiomyoma, i.e.
F. Ciccarone, A. Rizzi, A. Biscione, G. Baldassari, E. H. Tran, T. Pasciuto, F. Moro, G. Zinicola, F. Buonomo, M. Colombin, F. Ghezzi, J. Casarin, R. Mancari, F. Borella, A. Kardhashi, M. Roccio, L. Savelli, R. Cioffi, F. Fanfani, G. Ferrandina, G. Scambia, L. Valentin, D. Lorusso, A. C. Testa   +23 more
wiley   +1 more source

Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging

VIEW, EarlyView.
Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao, Jingyu Deng, Qin Li, Tong Xia, Xun Yang, Simei Yang, Changzhen Sun, Xia Xiong, Li Liu   +8 more
wiley   +1 more source

hUCMSC mitochondrial EVs confer neuroprotection after ischemia by Tom1l2-mediated mitochondrial fusion and Crls1-cardiolipin axis reprogramming. [PDF]

Redox Biol
Li Z, Zhu X, Liao W, Jiang R, Sang E, Zhu J, Sun G, Lu Z, Wang C, Jiang Y, Chen J, Gong P, Liu Q.   +12 more
europepmc   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

Experimental absorption corrections for highly absorbing europium compounds in powder neutron diffraction

Journal of Applied Crystallography, EarlyView.
An experimental method for absorption correction of powder samples containing highly neutron absorbing elements is reported.For materials with strong neutron absorption, such as europium (Eu), the absorption correction method is important but difficult to manage. This is because Eu has a strong isotope dependence. The energy dependence of absorption is
A. Hoshikawa, K. Kuwahara, C. Sekine
wiley   +1 more source

Human umbilical mesenchymal stem cell-derived mitochondria transplantation suppresses sFLT-1 secretion by regulating calcineurin-NFAT-dependent pathways in angiotensin II-induced preeclampsia rats. [PDF]

Stem Cell Res Ther
Cui HX, Liu JX, Kang YC, Han K, Lee HK, Kim CH, Zhang YH.   +6 more
europepmc   +1 more source