Results 141 to 150 of about 62,676 (260)

Plasma-derived mitochondria as a minimal manipulation alternative for attenuating inflammatory immune responses. [PDF]

Regen Biomater
Kim SH, Back ES, Lim I, Lim M, Kim MJ, Min K, Yun CK, Choi YS.   +7 more
europepmc   +1 more source

The War of the Pacific and Chilean public revenues: Reallocation of the tax burden and institutional change

The Economic History Review, EarlyView.
Abstract A substantial body of literature has considered warfare a fundamental driver of fiscal capacity. We argue that the nature of the tax base available to governments can either foster or constrain the ability and incentives of central elites to impose their legitimacy once the war is over.
Oriol Sabaté, José Peres‐Cajías
wiley   +1 more source

Mitochondria-localized photocatalyst of biomimetic organic semiconductor nanoparticles for NIR-activatable photocatalytic immunotherapy. [PDF]

Sci Adv
Wang Y, Gao Y, Yang Y, Zhang J, Wan Y, Li X, Li N, Fu G, Yang Y, Li Z, Zhao Q, Chen Y, Li S.   +12 more
europepmc   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Plasmodium falciparum stomatin-like protein forms a putative complex with a metalloprotease in distinct mitochondrial loci. [PDF]

PLoS Pathog
Verhoef JMJ, Bekkering ET, Boshoven C, Hannon M, Evers F, Proellochs NI, Spruijt CG, Kooij TWA.   +7 more
europepmc   +1 more source

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, EarlyView.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source

Dissecting discordance of mitochondrial and nuclear phylogenetic trees in insects. [PDF]

Crop Health
Mi X, Ou GZ, Zhu Y, Shen XX.
europepmc   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

A near-infrared fluorescent probe for dynamic HClO monitoring in epilepsy and high-throughput discovery of natural neuroprotectants. [PDF]

Redox Biol
Yin Q, Hou C, Zhang D, Li M, Zhang M, Ye T, Shi Y, Gai Z, Li B, Yan B.   +9 more
europepmc   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source