Results 211 to 220 of about 616,240 (353)

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

RAB7B as a Potential Therapeutic Target in Liver Cirrhosis: Insights from Protein Expression and Bioinformatics Analyses. [PDF]

ACS Omega
Dai J, Ying S, Lin J, Pan Y, Zhang Q, Liu J, Lou Y, Qiu Y.   +7 more
europepmc   +1 more source

El mito de la fuerza de Coriolis

, 2004
Itziar Alkorta, Isabel Albizu, Carlos Garbisu   +2 more
openalex   +1 more source

Impacts of Mitochondrial Status After Neoadjuvant Chemotherapy in Esophageal Squamous Cell Carcinoma Patients

Cancer Science, EarlyView.
We described the prognostic impacts of mitochondrial status after neoadjuvant chemotherapy and its association with the tumor microenvironment in esophageal squamous cell carcinoma patients. High Mito‐score after NAC identifies ESCC patients with significantly poorer survival, particularly among those with advanced pathological stages, thereby possibly
Kotaro Sugawara, Shingo Sakashita, Takashi Fukuda, Chiaki Murakami, Daiji Oka, Gulanbar Amori, Yoshifumi Baba, Hiroaki Kanda, Noriko Motoi   +8 more
wiley   +1 more source

Regulatory role of sirtuin-1 by targeting MDM2 to mitochondria-associated membranes formation in the treatment of NAFLD. [PDF]

Cell Commun Signal
Zhang R, Zhang Q, Cui Z, Huang B, Li M, Ma H.   +5 more
europepmc   +1 more source

Três mitos, três incômodas verdades sobre o agronegócio brasileiro

Flávio Sacco dos Anjos, José Marcos Froehlich, Nádia Velleda Caldas   +2 more
openalex   +2 more sources

Cuatro mitos y una propuesta para construir paz en Colombia

, 2019
Sánchez Cardona, Mariela Inés
openalex   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

QUEBRANDO MITOS E DESVENDANDO OS CAMINHOS DA EVOLUÇÃO HUMANA

Millena Ferreira da Silva, Ana Cristina Lauer Garcia, FERNANDA CRISTINA BEZERRA LEITE, IÊDA FERREIRA DE OLIVEIRA, MARTÍN ALEJANDRO MONTES   +4 more
openalex   +1 more source