Results 271 to 280 of about 616,240 (353)

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu   +7 more
wiley   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen   +5 more
wiley   +1 more source

Tumor-intrinsic redox programming drives an SPP1-CD44 axis of immune suppression in uveal melanoma. [PDF]

open access: yesRedox Biol
Ge T   +9 more
europepmc   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese   +5 more
wiley   +1 more source

Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis. [PDF]

open access: yesNat Commun
Bunel B   +5 more
europepmc   +1 more source

Optimal neuromuscular performance requires motor neuron phosphagen kinases

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Motor neuron (MN) terminals in fruit flies, mice and humans contain phosphagen kinases, a key enzyme in their energy storage and buffering system. Here we knocked down the primary phosphagen kinase in fruit fly larvae (arginine kinase 1 (ArgK1)) but were surprised to find that MN endurance was unaffected.
Karlis A. Justs   +10 more
wiley   +1 more source

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