Results 281 to 290 of about 616,240 (353)

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Reprogramming chemically induced dimerization systems with genetically encoded nanobodies. [PDF]

Chem Sci
Wang T, Nonomura T, Cui M, Lan TH, Cai PX, He L, Zhou Y.   +6 more
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Impairment of mitochondrial quality control exacerbates diabetes-related atrial fibrillation by cGAS-STING signaling pathway and cardiomyocyte-macrophage crosstalk. [PDF]

Theranostics
Meng S, Duan J, Zhao J, Zhou Z, Sun B, Xu Y, Huang T, Hong T, Chen X, Su T, Yu L, Wang H.   +11 more
europepmc   +1 more source

From Earth to orbit: How to preserve muscle health in space and bed rest

Experimental Physiology, EarlyView.
Antonios Matsakas, Colleen Deane
wiley   +1 more source

Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease

Glia, Volume 74, Issue 3, March 2026.
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar, Yucheng Xiao, Neha Mahajan, Qianyi Luo, Theodore R. Cummins, Adrian L. Oblak, Bruce T. Lamb, Timothy W. Corson, Ashay D. Bhatwadekar   +8 more
wiley   +1 more source

UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines. [PDF]

Nat Commun
Liu Z, Chen W, Zhang J, Huang T, Hong Y, Zhao T, Liu M, Chen Q, Yang Y, Wang S, Wang J, Ying X, Li Y, Huang Q, Ai K.   +14 more
europepmc   +1 more source

Planning in management: identifying alternative ways of improving performance toward best practices

International Transactions in Operational Research, Volume 33, Issue 2, Page 1362-1384, March 2026.
Abstract Planning is an important part of the management of organizations, which deals with the setting of targets that guide the actions needed to improve performance. Decision making is at the essence of planning, as it involves the identification of alternative directions for improvement and the selection of a future course of action.
Juan F. Monge, José L. Ruiz
wiley   +1 more source

[Not just frailty-Sjögren's syndrome and polymyositis with mitochondrial pathology]. [PDF]

Z Rheumatol
Kremer P, Melderis S, Matschke J, Stenzel W, Kötter I, Krusche M, Holzer MT.   +6 more
europepmc   +1 more source

Mito

, 2010
openaire   +1 more source