Transplantation of active mitochondria condensed in liquid-liquid phase-separated hydrogels ameliorates myocardial ischemia-reperfusion injury. [PDF]
Ai J +12 more
europepmc +1 more source
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang +7 more
wiley +1 more source
ER-mitochondria tether ML1 coordinates peripheral fission and wholesale mitophagy for plant adaptation to carbon starvation. [PDF]
Shi B +8 more
europepmc +1 more source
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney +10 more
wiley +1 more source
Holistic therapeutic philosophy: Boost a cascade communication between endoplasmic reticulum-mitochondria-lysosome to overload intracellular Ca<sup>2+</sup> and initiate chemoimmunotherapy. [PDF]
Su Y +6 more
europepmc +1 more source
RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal +4 more
wiley +1 more source
Role of ROS, soluble guanylate cyclase and cGMP in mouse lung development during hyperoxia. [PDF]
Nguyen ML +4 more
europepmc +1 more source
A Metal-Phenolic Nanocluster Orchestrates Mito-Ca<sup>2+</sup> Metabolic Autonomy for Tumor Ca<sup>2+</sup> Interference Therapy. [PDF]
Chen R +13 more
europepmc +1 more source
Correction: Knockout of a single aquaporin, OsPIP2;4, decreases root water permeability in rice. [PDF]
Onishi A +9 more
europepmc +1 more source

