Results 41 to 50 of about 618,328 (350)

初級後半における物語創作活動 [PDF]

, 2013
Oral PresentationConference Theme: Japanese Language Proficiency in Asia: Learners’ Sociolinguistic Competence and Diversity in Practice初級の後半になると、語彙や文法知識もかなり蓄積され、日本語で様々なことを理解・ 表現する能力が備わってくるが、学習者によっては頭の中にある知識が発話や作文といっ たアウトプットに結びついていないように見受けられるケースもある ...
Mito, A
core  

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Factors associated with failure of bony union after conservative treatment of acute cases of unilateral lumbar spondylolysis

BMC Musculoskeletal Disorders, 2021
Background If bone union is expected, conservative treatment is generally selected for lumbar spondylolysis. However, sometimes conservative treatments are unsuccessful.
Masaki Tatsumura, Hisanori Gamada, Shun Okuwaki, Fumihiko Eto, Katsuya Nagashima, Takeshi Ogawa, Takeo Mammoto, Atsushi Hirano, Masao Koda, Masashi Yamazaki   +9 more
doaj   +1 more source

Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins [PDF]

, 2018
Objective—We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. Approach and Results—Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and ...
Audi, Said H., Beyer, Andreas M., Clough, Anne V., Durand, Matthew J., Ebben, Johnathan D., Hill, R. Blake, Jacobs, Elizabeth R., Ma, Cui, Medhora, Meetha, Terashvili, Maia, Toro, Laura Norwood, Zhu, Daling   +11 more
core   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Contrast Agent Pooling in the Descending Aorta Due to Severe Heart Failure

Clinical Practice and Cases in Emergency Medicine
Case presentation: An 86-year-old female presented to our emergency department with chest pain and orthopnea and was diagnosed with heart failure and ST-elevation myocardial infarction, prompting hospitalization.
Yosuke Maezawa, Kazuya Nagasaki, Hiroyuki Kobayashi, Shunsuke Sakai, Toshiyuki Irie   +4 more
doaj   +1 more source

Features of sacral alar fatigue fractures in adolescent athletes with overuse

Scientific Reports, 2021
Three types of sacral alar fatigue fractures are elderly, postnatal, and sport-related. They are most prevalent in athletes during adulthood; there are few reports of sacral alar fatigue fractures in young athletes.
Masaki Tatsumura, Fumihiko Eto, Katsuya Nagashima, Shun Okuwaki, Hisanori Gamada, Sho Iwabuchi, Takeshi Ogawa, Takeo Mammoto, Atsushi Hirano, Masashi Yamazaki   +9 more
doaj   +1 more source

Atmospheric monitoring in the mm and sub-mm bands for cosmological observations: CASPER2

, 2012
Cosmological observations from ground at millimetre and sub-millimetre wavelengths are affected by atmospheric absorption and consequent emission. The low and high frequency (sky noise) fluctuations of atmospheric performance imply careful observational ...
De Gregori, Simone, De Petris, Marco, Decina, Barbara, Lamagna, Luca, Pardo, Juan R.   +4 more
core   +1 more source

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources