Results 241 to 250 of about 302,571 (319)

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration. [PDF]

iScience
Franczak E, Montgomery MM, Terwilliger ZS, Aruleba RT, Krassovskaia P, Boykov IN, Hagen JT, Pacheco EA, Chrest BR, Zeczycki TN, Vandiver KJ, Neufer PD, McClung JM, Fisher-Wellman KH.   +13 more
europepmc   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

Untersuchungen zur Cytotopik und Struktur der Proteinsynthesesysteme in der Thoraxmuskulatur von Locusta migratoria [PDF]

, 1973
Kleinow, W., Neupert, Walter
core  

Oxaloacetic Decarboxylase from Rat Liver Mitochondria

Journal of Biological Chemistry, 1959
openaire   +2 more sources

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source

Mitochondrial stress as a conceptual interface between bacterial infection and post-infectious metabolic disease. [PDF]

Front Cell Infect Microbiol
Plaza N, Pérez-Reytor D, Corsini G, García K, Urrutia ÍM.   +4 more
europepmc   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Decoding mitochondrial signaling: neutrophil-tumor cell crosstalk in orchestrating cancer progression. [PDF]

J Transl Med
Shen Q, Pan X, Li J, Li Y, Lin J, Liu F, Jiang X, Zhang C, Pang B.   +8 more
europepmc   +1 more source