Results 241 to 250 of about 2,143,132 (361)

NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis. [PDF]

Nat Commun
Sun Z, Sun L, Hua H, Ren Y, Zhu W, Wang X, Gu W, Huang S, Zhong D, Sun Y, Zhang Y, Zhang A, Jia Z.   +12 more
europepmc   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Restoring metabolic flexibility: targeting organelle interaction networks in the pathogenesis and therapy of MASLD. [PDF]

Front Cell Dev Biol
Liu Y, Wang Y, Zhou J, Li H, Liu C, Zhong B, Liu J, Liu L, Zhang L, Sun L.   +9 more
europepmc   +1 more source

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Nature Cell Biology, 2019
Amado Carreras-Sureda, F. Jaña, H. Urra, Sylvère Durand, Sylvère Durand, D. E. Mortenson, Alfredo I Sagredo, Galdo Bustos, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, M. Sassano, Philippe Pihán, A. V. Vliet, Matías González-Quiroz, Angie K Torres, Cheril Tapia-Rojas, M. Kerkhofs, R. Vicente, R. Kaufman, N. Inestrosa, C. González-Billault, C. González-Billault, R. Wiseman, P. Agostinis, G. Bultynck, F. Court, G. Kroemer, J. C. Cardenas, C. Hetz   +29 more
semanticscholar   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

Acteoside Ameliorates Hepatic Steatosis and Liver Injury in MASLD Mice Through Activation of PINK1/Parkin-Related Mitophagy Markers. [PDF]

Nutrients
Cong M, Qi X, Sun H, Zhang X, Yan Y, Liu T, Zhao J.   +6 more
europepmc   +1 more source

A Specific Adenosinetriphosphatase of Liver Mitochondria

Journal of Biological Chemistry, 1953
W W, KIELLEY, R K, KIELLEY
openaire   +2 more sources

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

Int J Mol Sci
Mastoridou EM, Goussia AC, Kataki A, Koniaris E, Glantzounis GK, Papoudou-Bai A, Kanavaros P, Charchanti AV.   +7 more
europepmc   +1 more source