Results 251 to 260 of about 302,571 (319)

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function. [PDF]

Cell Death Dis
Qin Y, Teker SS, La Cunza N, Tong Y, Theusch E, Yang NV, Venkatesan L, Su J, Wang X, Krauss RM, Lakkaraju A, Mattis AN, Medina MW.   +12 more
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Psoralidin, a main compound in Psoraleae Fructus, induces hepatotoxicity by impeding lipid oxidative catabolism and aggravating lipid accumulation in mice. [PDF]

Chin Med
Guo Z, Peng X, Qin D, Zhang L, Tu C, Wang T.   +5 more
europepmc   +1 more source

Lipoyl Dehydrogenase from Beef Liver Mitochondria

Journal of Biological Chemistry, 1963
openaire   +2 more sources

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

AMPK maintains the activation of hepatic stellate cells through mitophagy-induced metabolic reprogramming. [PDF]

J Mol Cell Biol
Wang H, Wang G, Yin T, Li H, Wang H, Shao Y, Li Y, Hua R, Li J, Zang Y.   +9 more
europepmc   +1 more source

Lipid overload triggers PERK-ALCAT1-mediated mitophagy failure in hepatocytes. [PDF]

iScience
Zhao W, Bao Y, Liu L, Gu Y, Liu X, Monroig Ó, Zhu T, Sun P, Tocher DR, Zhou Q, Jin M.   +10 more
europepmc   +1 more source

3D Mitochondria Shape Library for Optical Microscopy (3DMSL): A multimodal dataset for deep learning based mitochondrial analysis. [PDF]

Data Brief
Punnakkal AR, Jadhav SS, Celeste AV, Horsch A, Agarwal K, Prasad DK.   +5 more
europepmc   +1 more source