Results 241 to 250 of about 1,196,029 (309)

Spica Prunellae attenuates ER stress via GRP78/IRE1α/JNK pathway in CCL₄-induced acute liver injury in mice. [PDF]

Front Pharmacol
Wang Y, Hao J, Yang J, Dai Q, Chen Z, Han F, Zhang Y, Zhang H.   +7 more
europepmc   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Ferroptosis in liver biology and diseases. [PDF]

Hepatol Commun
Cao P, He P, Du K, Jaeschke H, Lemasters JJ, Chen Y, Wong CC, Ding WX.   +7 more
europepmc   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Mitochondrial immunometabolism in sepsis: bridging immune cell dysfunction and organ failure. [PDF]

Front Immunol
Zhang X, Zhao L, Fu W, Pan L, Wu H, Peng J.   +5 more
europepmc   +1 more source

Mitochondrial Dysfunction in Metabolic-Syndrome-Related MASLD/MASH: Metabolic Mechanisms and Therapeutic Perspectives. [PDF]

Metabolites
Jin J, Cheng Y.
europepmc   +1 more source

Mitochondrial dysfunction and lipid droplet dynamics in MASH: HSD17B13 as a therapeutic target. [PDF]

Front Cell Dev Biol
Noor S, Tian Y, Su W.
europepmc   +1 more source

Mitophagy in Metabolic Dysfunction-Associated Fatty Liver Disease: Mechanisms, Regulatory Networks, and Therapeutic Perspectives. [PDF]

Inflammation
Liu Z, Zhang S, Zeng T.
europepmc   +1 more source