Results 71 to 80 of about 264,171 (312)

THE MITOCHONDRIA OF INSECT FLIGHT MUSCLE [PDF]

Journal of Histochemistry & Cytochemistry, 1953
It has been known for over a century that the ifight muscles of insects belonging to the two orders Diptera (the true ffies), and Hymenoptera (ants, bees and wasps) are specialized in certain aspects of their morphology to a degree not found in other groups of insects.
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Pathology of mitochondria in MELAS syndrome: an ultrastructural study

Polish Journal of Pathology, 2017
Ultrastructural changes in skeletal muscle biopsy in a 24-year-old female patient with clinically suspected mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS) syndrome are presented.
Paulina Felczak, Eliza Lewandowska, Iwona Stępniak, Monika Ołdak, Agnieszka Pollak, Urszula Lechowicz, Elżbieta Pasennik, Tomasz Stępień, Teresa Wierzba-Bobrowicz   +8 more
doaj   +1 more source

Ambra1 deficiency impairs mitophagy in skeletal muscle

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Maintaining healthy mitochondria is mandatory for muscle viability and function. An essential surveillance mechanism targeting defective and harmful mitochondria to degradation is the selective form of autophagy called mitophagy.
Lisa Gambarotto, Samuele Metti, Martina Chrisam, Cristina Cerqua, Patrizia Sabatelli, Andrea Armani, Carlo Zanon, Marianna Spizzotin, Silvia Castagnaro, Flavie Strappazzon, Paolo Grumati, Matilde Cescon, Paola Braghetta, Eva Trevisson, Francesco Cecconi, Paolo Bonaldo   +15 more
doaj   +1 more source

Proteolytic Processing of OPA1 Links Mitochondrial Dysfunction to Alterations in Mitochondrial Morphology [PDF]

, 2006
Many muscular and neurological disorders are associated with mitochondrial dysfunction and are often accompanied by changes in mitochondrial morphology.
Attardi, Giuseppe, Bauer, Matthis F., Chomyn, Anne, Duvezin-Caubet, Stéphane, Hansson, Anna, Hofmann, Sabine, Jagasia, Ravi, Larsson, Nils-Göran, Neupert, Walter, Reichert, Andrea S., Trifunovic, Aleksandra, Wagener, Johannes   +11 more
core   +2 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia

Biomolecules
Sarcopenia has a complex pathophysiology that encompasses metabolic dysregulation and muscle ultrastructural changes. Among the drivers of intracellular and ultrastructural changes of muscle fibers in sarcopenia, mitochondria and their quality control ...
Emanuele Marzetti, Biliana Lozanoska-Ochser, Riccardo Calvani, Francesco Landi, Hélio José Coelho-Júnior, Anna Picca   +5 more
doaj   +1 more source

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]

, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow, A Bartelt, AM Cypess, Ayano Ueno, B Tasic, C Jang, Carlos Henrique Sponton, CB Newgard, CB Newgard, CJ Lynch, CR Green, CT Ferrara, DE Lackey, EG Sustarsic, F Palmieri, Francis C. Szoka, H Ohno, Haruya Takahashi, Hiroko Maki, Homa Majd, Huixia Li, K Ikeda, K Shinoda, Kaori Igarashi, Kazuki Tajima, KC Das, Kenji Ikeda, KH Pietiläinen, KM Huffman, Kyeongkyu Kim, LA Gilbert, Labros Sidossis, M Chondronikola, M Rosell, M Saito, M Wallace, MA Herman, Maki Ohishi, Mami Matsushita, Maria Chondronikola, Masayuki Saito, MD Neinast, Michael T. McManus, Mito Kuroda, Momoko Yoneshiro, Olga R. Ilkayeva, P She, Phillip J. White, PJ White, PJ White, Qiang Wang, Rachana N. Pradhan, Robert W. McGarrah, SH Um, Shingo Kajimura, T Li, T Soga, T Soga, T Yoneshiro, Takamasa Ishikawa, Takeshi Yoneshiro, Teruo Kawada, TJ Wang, Tomoyoshi Soga, Tsuyoshi Goto, V Ouellet, Vanille Juliette Greiner, X Kong, Yann Deleye, Yasuo Oguri, Yong Chen, Zachary Brown, Zhipeng Dai   +72 more
core   +1 more source

Ca ion transport in smooth muscle mitochondria [PDF]

The Ukrainian Biochemical Journal, 2014
Review focuses on the analysis of literature data and own results concerning properties of mitochondria Ca2+ transporting systems and their regulation. Three mechanisms for mitochondrial Ca2+ uptake are described: the electrogenic mitochondrial Ca2+ uniporter, a rapid mode of Ca2+ uptake (RaM) and ryanodine-sensitive Ca2+ channels (RyR). Two mechanisms
L. G. Babich, S. G. Shlykov, S. O. Kosterin   +2 more
openaire   +3 more sources

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source