Results 61 to 70 of about 1,131,582 (303)
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]
, 1993 Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
W Neupert +5 more
core +2 more sources
Mitochondrial Function and Reactive Oxygen/Nitrogen Species in Skeletal Muscle
Frontiers in Cell and Developmental Biology, 2022 Skeletal muscle fibers contain a large number of mitochondria, which produce ATP through oxidative phosphorylation (OXPHOS) and provide energy for muscle contraction.
Ming-Ming Chen +5 more
doaj +1 more source
Comparing Electron Leak in Vertebrate Muscle Mitochondria [PDF]
Integrative and Comparative Biology, 2018 Mitochondrial electron transfer for oxidative ATP regeneration is linked to reactive oxygen species (ROS) production in aerobic eukaryotic cells. Because they can contribute to signaling as well as oxidative damage in cells, these ROS have profound impact for the physiology and survival of the organism.
Treberg, J.R. +5 more
openaire +3 more sources
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Ambra1 deficiency impairs mitophagy in skeletal muscle
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Maintaining healthy mitochondria is mandatory for muscle viability and function. An essential surveillance mechanism targeting defective and harmful mitochondria to degradation is the selective form of autophagy called mitophagy.
Lisa Gambarotto +15 more
doaj +1 more source
Efeito da diabetes mellitus tipo 1 na função mitocondrial [PDF]
, 2011 Mestrado em Bioquímica-Métodos BiomulecularesDespite type 1 diabetes mellitus being more rare, it has an autoimmune origin and appears early in life, greatly affecting its quality.
Carvalho, Tiago Filipe Cruz
core
Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells
, 2020 Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology and pathophysiology. The cytoskeleton (microtubules, intermediate filaments,
Andrey V. Kuznetsov +5 more
core +1 more source
An Epigenetic Role of Mitochondria in Cancer
, 2022 Mitochondria are not only the main energy supplier but are also the cell metabolic center regulating multiple key metaborates that play pivotal roles in epigenetics regulation.
Sun, Yihong +13 more
core +1 more source
Advanced Science, EarlyView.The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun +7 more
wiley +1 more source