Results 91 to 100 of about 1,007,169 (424)

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]

, 2017
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui, Chandel, Navdeep S, DeBerardinis, Ralph J, Dickerson, Kathryn E, Gu, Zhimin, Hu, Zeping, Li, Dan, Li, Mushan, Liu, Xin, Ni, Min, Shao, Zhen, Signer, Robert AJ, Weinberg, Samuel E, Xu, Jian, Zhang, Yuannyu, Zhou, Feng   +15 more
core   +1 more source

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Stable deep neural network architectures for mitochondria segmentation on electron microscopy volumes [PDF]

arXiv, 2021
Electron microscopy (EM) allows the identification of intracellular organelles such as mitochondria, providing insights for clinical and scientific studies. In recent years, a number of novel deep learning architectures have been published reporting superior performance, or even human-level accuracy, compared to previous approaches on public ...
arxiv  

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Impact of Preparative Isolation of C-Glycosylflavones Derived from Dianthus superbus on In Vitro Glucose Metabolism

Molecules
Dianthus superbus L. has been extensively studied for its potential medicinal properties in traditional Chinese medicine and is often consumed as a tea by traditional folk.
Zikai Lin, Xiaowei Zhou, Chen Yuan, Yan Fang, Haozheng Zhou, Zhenhua Wang, Jun Dang, Gang Li   +7 more
doaj   +1 more source

Evolution of Physical Status From Diagnosis to the End of First-Line Treatment in Breast, Lung, and Colorectal Cancer Patients: The PROTECT-01 Cohort Study Protocol

Frontiers in Oncology, 2020
Background: Cancer cachexia and exacerbated fatigue represent two hallmarks in cancer patients, negatively impacting their exercise tolerance and ultimately their quality of life.
Joris Mallard, Joris Mallard, Elyse Hucteau, Elyse Hucteau, Roland Schott, Thierry Petit, Martin Demarchi, Christine Belletier, Meher Ben Abdelghani, Hélène Carinato, Pascale Chiappa, Cathie Fischbach, Michal Kalish-Weindling, Audren Bousinière, Stéphane Dufour, Fabrice Favret, Xavier Pivot, Thomas J. Hureau, Allan F. Pagano   +18 more
doaj   +1 more source

MitoVis: A Visually-guided Interactive Intelligent System for Neuronal Mitochondria Analysis [PDF]

arXiv, 2021
Neurons have a polarized structure, including dendrites and axons, and compartment-specific functions can be affected by dwelling mitochondria. It is known that the morphology of mitochondria is closely related to the functions of neurons and neurodegenerative diseases.
arxiv  

Localization of TCA cycle dehydrogenases in the mitochondria [PDF]

, 1967
The site of localization of TCA cycle dehydrogenases in mitochondria has been investigated by observing the dehydrogenase activities and fine structure of the fractionated samples after freezing and thawing or sonication of beef heart and rat liver ...
Inaba, Kozo, Oda, Takuzo, Wakabayashi, Akira   +2 more
core   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome

Cells, 2020
Tafazzin is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation.
Patrice X. Petit, Hector Ardilla-Osorio, Lucile Penalvia, Nathan E. Rainey   +3 more
doaj   +1 more source