Results 91 to 100 of about 698,916 (379)
BiologyThe anti-inflammatory and analgesic properties of cannabis might be useful to treat muscle diseases, including those linked or not to alcohol. Nevertheless, delta 9 tetrahydrocannabinol (THC) and ethanol (EtOH), often used concomitantly, can have ...
Anne-Laure Charles +8 more
doaj +1 more source
MitoSeg: Mitochondria Segmentation Tool [PDF]
Recent studies suggest a potential link between the physical structure of mitochondria and neurodegenerative diseases. With advances in Electron Microscopy techniques, it has become possible to visualize the boundary and internal membrane structures of mitochondria in detail.
arxiv +1 more source
Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Mitochondria and lysosomes are critical for cellular homeostasis and defects in both organelles are observed in several diseases. Recently, contact sites between mitochondria and lysosomes were identified and found to modulate mitochondrial ...
Wesley J Peng, Y. Wong, D. Krainc
semanticscholar +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Mitochondria Revisited. Alternative Functions of Mitochondria
Bioscience Reports, 1997 This review explores the alternative functions of mitochondria inside the cell. In a general picture of mitochondrial functioning, the importance and uniqueness of these intrinsic functions make them irreplaceable by other intracellular compartments.
Ljubava D. Zorova +4 more
openaire +3 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Molecules, 2020 Characterization of the structure and pharmacological activity of Berberis dasystachya Maxim., a traditional Tibetan medicinal and edible fruit, has not yet been reported.
Lijuan Han +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
MoleculesThe reason why young people taking concomitantly cannabis (THC) and ethanol (EtOH) are more prone to stroke is underresearched. To investigate whether an underlying mechanism of increased brain damage could be an impaired mitochondrial function, this ...
Véronique Quenardelle +5 more
doaj +1 more source
Metabolic Modulation of Macrophage Function Post Myocardial Infarction
Frontiers in Physiology, 2020 Macrophages are key components of innate immunity, and they play critical roles in heart health and diseases. Following acute myocardial infarction (MI), infiltrating macrophages undergo drastic phenotypic transition from pro-inflammatory in the early ...
Mingyue Zhao +5 more
doaj +1 more source