Overproduction of PDR3 Suppresses Mitochondrial Import Defects Associated with a TOM70 Null Mutation by Increasing the Expression of TOM72 in Saccharomyces cerevisiae [PDF]
, 2001 Most mitochondrial proteins are synthesized with cleavable amino-terminal targeting signals that interact with the mitochondrial import machinery to facilitate their import from the cytosol.
Bedwell, David M. +2 more
core +1 more source
Cas9/gRNA-mediated genome editing of yeast mitochondria and Chlamydomonas chloroplasts [PDF]
PeerJ, 2020 We present a new approach to edit both mitochondrial and chloroplast genomes. Organelles have been considered off-limits to CRISPR due to their impermeability to most RNA and DNA.
Byung-Chun Yoo +3 more
doaj +2 more sources
Broad genomic and transcriptional analysis reveals a highly derived genome in dinoflagellate mitochondria [PDF]
BMC Biology, 2007 Abstract Background Dinoflagellates comprise an ecologically significant and diverse eukaryotic phylum that is sister to the phylum containing apicomplexan endoparasites. The mitochondrial genome of apicomplexans is uniquely reduced in gene content and size, encoding only three proteins and two ribosomal RNAs (rRNAs)
Jackson, Christopher J +5 more
openaire +4 more sources
The arabidopsis COX11 homolog is essential for cytochrome c oxidase activity [PDF]
, 2015 Members of the ubiquitous COX11 (cytochrome c oxidase 11) protein family are involved in copper delivery to the COX complex. In this work, we characterize the Arabidopsis thaliana COX11 homolog (encoded by locus At1g02410).
Mansilla, Natanael +3 more
core +2 more sources
DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology
Scientific Reports, 2017 Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused DNMT1-isoform1, reported earlier to localize in mitochondria, surprisingly showed its exclusive ...
Sunil Kumar Saini +3 more
doaj +1 more source
The SAR11 group of alpha-proteobacteria is not related to the origin of mitochondria.
PLoS ONE, 2012 Although free living, members of the successful SAR11 group of marine alpha-proteobacteria contain a very small and A+T rich genome, two features that are typical of mitochondria and related obligate intracellular parasites such as the Rickettsiales ...
Naiara Rodríguez-Ezpeleta +1 more
doaj +1 more source
Mitochondria-Targeted Drug Delivery
Pharmaceutics, 2022 Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centres [...]
Joanna Kopecka
doaj +1 more source
Genome Rearrangement in Mitochondria and Its Computational Biology
, 2005 In the first part of this paper, we investigate gene orders of closely related mitochondrial genomes for studying the properties of mutations rearranging genes in mitochondria. Our conclusions are that the evolution of mitochondrial genomes is more complicated than it is considered in recent methods, and stochastic modelling is necessary for its deeper
Miklos, I, Hein, J
openaire +2 more sources
Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
Cells, 2019 Mitochondria harbor their own genetic system, yet critically depend on the import of a number of nuclear-encoded macromolecules to ensure their expression.
Damien Jeandard +5 more
doaj +1 more source
ncRNAs: New Players in Mitochondrial Health and Disease?
Frontiers in Genetics, 2020 The regulation of mitochondrial proteome is unique in that its components have origins in both mitochondria and nucleus. With the development of OMICS technologies, emerging evidence indicates an interaction between mitochondria and nucleus based not ...
Mirjana Gusic +4 more
doaj +1 more source