Results 81 to 90 of about 2,539,821 (192)

XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage

Nucleic Acids Research, 2015
Xeroderma pigmentosum group D (XPD/ERCC2) encodes an ATP-dependent helicase that plays essential roles in both transcription and nucleotide excision repair of nuclear DNA, however, whether or not XPD exerts similar functions in mitochondria remains ...
Jing Liu, Hong-Bo Fang, Zhen-Fen Chi, Zan Wu, D. Wei, Dongliang Mo, K. Niu, A. Balajee, T. Hei, L. Nie, Yongliang Zhao   +10 more
semanticscholar   +1 more source

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis [PDF]

, 2010
Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS.
Turnbull, Doug M, Kim J. Krishnan, Iryna Ziabreva, Owain Howell, Graham R. Campbell, Don J. Mahad, Reynolds, Richard, Owen Howell, Mahad, Don J, Reeve, Amy K, Amy K. Reeve, Richard Reynolds, Ziabreva, Iryna, Campbell, Graham R, Lassmann, Hans, Doug M. Turnbull, Howell, Owen, Krishnan, Kim J, Hans Lassmann   +18 more
core   +1 more source

Mitochondrial DNA Integrity: Role in Health and Disease

Cells, 2019
As the primary cellular location for respiration and energy production, mitochondria serve in a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria are subject to constant oxidative stress that can damage one ...
Priyanka Sharma, Harini Sampath
doaj   +1 more source

Mitochondria and cell death signalling.

Current Opinion in Cell Biology
Mitochondria are essential organelles in the life and death of a cell. During apoptosis, mitochondrial outer membrane permeabilisation (MOMP) engages caspase activation and cell death.
Ella Hall-Younger, S. Tait
semanticscholar   +1 more source

Enzymes involved in organellar DNA replication in photosynthetic eukaryotes

Frontiers in Plant Science, 2014
Plastids and mitochondria possess their own genomes. Although the replication mechanisms of these organellar genomes remain unclear in photosynthetic eukaryotes, several organelle-localized enzymes related to genome replication, including DNA polymerase,
Takashi eMoriyama, Takashi eMoriyama, Naoki eSato, Naoki eSato   +3 more
doaj   +1 more source

Focusing on mitochondria in the brain: from biology to therapeutics

Translational Neurodegeneration
Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of many organs and tissues, among which the ...
Nanshan Song, Shuyuan Mei, Xiangxu Wang, Gang Hu, Ming Lu   +4 more
semanticscholar   +1 more source

Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites [PDF]

, 2014
EH and TAW acknowledge support from the Marie Curie Fellowship Programme (HTTP://cordis.europa.eu/fp7/home_en.html). ERSK, JML and TME acknowledge support from the Wellcome Trust (www.wellcome.ac.uk/).
Eva Heinz (105025), Hirt, R.P., Edmund R. S. Kunji (669696), Williams, Tom A, Goldberg, A.V., Robert P Hirt, Hacker Christian, T Martin Embley, Robert P. Hirt (124609), Kunji, E.R.S., Nakjang, Sirintra, Kunji, Edmund R S, John M. Lucocq (124603), Embley, T. Martin, Christian Hacker (124601), Edmund R S Kunji, Alina V. Goldberg (124596), Heinz, Eva, John Mifsud (669694), Lucocq, John M., Alison Gregory, Embley T. Martin, Dean, P., Hirt, Robert P., Goldberg, Alina V, Heinz, E., Nakjang Sirintra, T. Martin Embley (124611), Williams Tom A., Sirintra Nakjang (124590), Kunji, Edmund R. S., John M Lucocq, Gregory, Alison, Goldberg Alina V., Tom A Williams, Tom A. Williams (124587), Gregory, A., Lucocq John M., Embley, T Martin, Paul Dean (35800), Heinz Eva, Dean, Paul; id_orcid, John Mifsud, Williams, Tom A., Lucocq, John M, Hirt Robert P., Alina V Goldberg, Dean, Paul, Hirt, Robert P, Paul Dean, Nakjang, S., Sirintra Nakjang, Gregory Alison, Dean Paul, Goldberg, Alina V., Mifsud, John, Williams, T.A., Mifsud John, Christian Hacker, Alison Gregory (669695), Embley, T.M., Eva Heinz, Hacker, Christian, Hacker, C., Kunji, Edmund R.S., Mifsud, J., Kunji Edmund R. S.   +66 more
core   +1 more source

An energetic view of stress: Focus on mitochondria

Frontiers in neuroendocrinology (Print), 2018
Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is largely derived from mitochondria – unique multifunctional organelles with their own genome.
M. Picard, B. McEwen, E. Epel, C. Sandi
semanticscholar   +1 more source

The curious case of vanishing mitochondria

, 2016
Due to their involvement in the energy metabolism, mitochondria are essential for most eukaryotic cells. Microbial eukaryotes living in low oxygen environments possess reduced forms of mitochondria, namely mitochondrion-related organelles (MROs).
Anna Karnkowska, Vladimír Hampl
core   +1 more source

A simplified method to isolate rice mitochondria

Plant Methods, 2020
Background Mitochondria play critical roles in plant growth, development and stress tolerance. Numerous researchers have carried out studies on the plant mitochondrial genome structure, mitochondrial metabolism and nuclear-cytoplasmic interactions ...
Yanghong Xu, Xiaoyi Li, Jishuai Huang, Leilei Peng, Dinghui Luo, Qiannan Zhang, Zhiwu Dan, Haijun Xiao, Fang Yang, Jun Hu   +9 more
doaj   +1 more source