Results 111 to 120 of about 712,444 (333)

The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis

Acta Pharmacologica Sinica, 2020
Mitochondria serve as sensors of energy regulation and glucose levels, which are impaired by diabetes progression. Catalpol is an iridoid glycoside that exerts a hypoglycemic effect by improving mitochondrial function, but the underlying mechanism has ...
Dengqiu Xu, Chun-jie Li, Zhen Jiang, Lu Wang, Hong-fei Huang, Zhi-Jian Li, Li-Xin Sun, Si-si Fan, Lu-Yong Zhang, Tao Wang   +9 more
semanticscholar   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Biogenesis of cytochrome c1 [PDF]

, 1989
The biogenesis of cytochrome c1 involves a number of steps including: synthesis as a precursor with a bipartite signal sequence, transfer across the outer and inner mitochondrial membranes, removal of the first part of the presequence in the matrix ...
Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A.   +2 more
core  

Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy [PDF]

, 2019
The mosaic distribution of cytochrome c oxidase(+) (COX+) and COX - muscle fibers in mitochondrial disorders allows the sampling of fibers with compensated and decompensated mitochondrial function from the same individual.
Doll, S., Geyer, P., Klopstock, T., Mann, M., Murgia, M., Tan, J.   +5 more
core   +3 more sources

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

Molecular Neurodegeneration, 2020
Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However, compelling evidence to causatively
Sheila K Pirooznia, Changqing Yuan, M. R. Khan, Senthilkumar S. Karuppagounder, Luan Wang, Yulan Xiong, Sung-Ung Kang, Yunjong Lee, V. Dawson, T. Dawson   +9 more
semanticscholar   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo   +23 more
wiley   +1 more source

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Neuronal mitochondria are crucial organelles that regulate bioenergetics and also modulate survival and function under environmental challenges.
Sashaina E Fanibunda, S. Deb, Babukrishna Maniyadath, Praachi Tiwari, Utkarsha Ghai, Samir Gupta, Dwight Figueiredo, N. Weisstaub, J. Gingrich, Ashok D B Vaidya, Ullas Kolthur-Seetharam, V. Vaidya   +11 more
semanticscholar   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2012
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Afonso, Azad, Besteiro, Betin, Betin, Bhattacharya, Boya, Cabrera, Dalle-Donne, Deretic, Dolai, Dolai, Garami, Geng, Goldman, Graef, Graham H. Coombs, Hosokawa, Jeremy C. Mottram, Kim, Kimura, Kimura, Kirisako, Kirisako, Krebiehl, Köchl, Lee, Lemasters, Li, Manjithaya, Mariño, Mariño, Mariño, Medina-Acosta, Misslitz, Mortensen, Mottram, Mörck, Mörck, Nair, Okamoto, Read, Roderick A.M. Williams, Sacks, Schapira, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Scherz-Shouval, Tanida, Tanida, Williams, Williams, Williams, Williams, Wong, Xie, Yoshimoto, Youle   +58 more
core   +1 more source

Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2019
Cellular senescence is a biological process by which cells lose their capacity to proliferate yet remain metabolically active. Although originally considered a protective mechanism to limit the formation of cancer, it is now appreciated that cellular ...
R. Summer, H. Shaghaghi, DeLeila Schriner, W. Roque, Dominic Sales, K. Cuevas-Mora, V. Desai, A. Bhushan, M. I. Ramirez, Freddy Romero   +9 more
semanticscholar   +1 more source