Results 131 to 140 of about 535,437 (290)

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Changes in TFAM binding at both origins of mitochondrial DNA replication are involved in the mitochondrial biogenesis alterations related to aging and calorie restriction in rat liver

, 2013
Mitochondrial biogenesis is among the organelle’s features affected by aging in tissue-specific ways. The only intervention, so far, able to delay or prevent the onset of several age-related changes, also in mitochondria, is calorie restriction (CR ...
PESCE, VITO, Joseph A. M., Leeuwenburgh C., Joseph AM, Picca A, LEZZA, Angela Maria Serena, Fracasso F, Fracasso F., Picca A.   +8 more
core  

OsPPR19, a rice pentatricopeptide repeat protein, is essential for mitochondrial biogenesis and seed development

Despite the accumulating evidence showing the essential role of pentatricopeptide repeat (PPR) proteins in organellar biogenesis and plant development in Arabidopsis thaliana and maize (Zea mays), the functions of most PPR proteins in rice (Oryza sativa)
KIM Yeon-Ok, Kwanuk LEE, Hunseung KANG, Jong-Seong JEON, Su Jung PARK   +4 more
core   +1 more source

Biogenesis of mitochondrial energy transducing complexes [PDF]

, 1987
Pfanner, Nikolaus, Neupert, Walter
core   +2 more sources

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

What can a unicellular parasite tell us about mitochondrial biogenesis?

, 2014
Most of what we know about mitochondrial biogenesis stems from work in yeast and mammals, which are quite closely related. To understand the conserved features of mitochondria and the evolutionary forces that shaped it, it is important to study a more ...
Schneider, André
core  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

mTOR-related linc-PMB promotes mitochondrial biogenesis via stabilizing SIRT1 mRNA through binding to the HuR protein

Acta Biochimica et Biophysica Sinica
Mitochondrial dysfunction is implicated in numerous disorders, including type 2 diabetes, Alzheimer’s disease and cancer. Long non-coding RNAs (lncRNAs) are emerging as pivotal regulators of cellular energy ...
Chen Qian, Zhang Huaying, Wang Daokun, Liao Wenjing, Liu Yazhou, Cai Yurui, Wang Siyou, Yu Mengqian   +7 more
doaj   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Mitochondrial biogenesis in trypanosomes - Expect the unexpected

, 2017
Trypanosomes have emerged as a novel system to study mitochondrial biogenesis that is essentially unrelated to yeast and mammals. Recently we have characterized the protein complexes in the outer and the inner membrane that mediate protein import.
Schneider, André
core