Results 181 to 190 of about 712,444 (333)

MYC and Mitochondrial Biogenesis [PDF]

, 2014
Fionnuala Morrish, David M. Hockenbery
openalex   +1 more source

Supplementary Table S3 from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

, 2023
Mengjie Zhao, Yanhui Li, Chenfei Lu, Fangshu Ding, Miao Xu, Xin Ge, Mengdie Li, Zhen Wang, Jianxing Yin, Junxia Zhang, Xiefeng Wang, Zehe Ge, Hong Xiao, Yong Xiao, Hongyi Liu, Wentao Liu, Yuandong Cao, Qianghu Wang, Yongping You, Xiuxing Wang, Kun Yang, Zhumei Shi, Xu Qian   +22 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

, 2022
Julie Steen Pedersen, Marte Opseth Rygg, Karoline Maise Chrøis, Elahu G. Sustarsic, Zachary Gerhart‐Hines, Nicolai J. Wewer Albrechtsen, Reza Serizawa, Viggo B. Kristiansen, A. Basse, Astrid E. B. Boilesen, Beth Hærstedt Olsen, Torben Hansen, Lise Lotte Gluud, Sten Madsbad, Steen Larsen, Flemming Bendtsen, Flemming Dela   +16 more
openalex   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission [PDF]

, 2019
Agrawal, Anyuan He, Aranovich, Babak Razani, Baes, Braverman, Cohen, Dodt, Fong-Fu Hsu, Gould, Hongsuk Park, Irfan J. Lodhi, John M. Dean, Jordan M. Johnson, Katsuhiko Funai, Lim, Min Tan, Terri A. Pietka, Wikstrom, Xiangyu Zhang, Yali Chen   +20 more
core   +2 more sources

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

High-dose vitamin C promotes mitochondrial biogenesis in HCT116 colorectal cancer cells by regulating the AMPK/PGC-1α signaling pathway

Journal of Cancer Research and Clinical Oncology
Background Mitochondrial dysfunction is closely associated with cancer development. Colorectal cancer (CRC) cells often exhibit altered energy metabolism, characterized by increased glycolysis and reduced oxidative phosphorylation.
RuiYang Hong, Su Min, Jia Huang, Mou Zou, DongYu Zhou, Yun Liang   +5 more
doaj   +1 more source

Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review

EFORT Open Reviews
The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) remains unclear; however, emerging evidence suggests that mitochondrial injury plays a significant role.
Yidan Yang, Yi Jian, Youwen Liu, Maoxiao Ma, Jiayi Guo, Bin Xu, Chen Yue   +6 more
doaj   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source