Results 71 to 80 of about 712,444 (333)

SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride

Theranostics, 2020
Rationale: Potential adverse effects of fluoride on neurodevelopment has been extensively explored and mitochondria have been recognized as critical targets.
Qian Zhao, Z. Tian, Guoyu Zhou, Q. Niu, Jingwen Chen, Pei-Yuan Li, Lixin Dong, T. Xia, Shun Zhang, Ai-guo Wang   +9 more
semanticscholar   +1 more source

Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. [PDF]

, 2015
Endurance exercise, when performed regularly as part of a training program, leads to increases in whole-body and skeletal muscle-specific oxidative capacity.
Acheson, Achten, Alemo Munters, Alexander, Andersen, Atherton, Baar, Baggish, Bartlett, Bartlett, Bassett, Beere, Bonen, Bonne, Boon, Bosselaar, Bravo, Bruckbauer, Buijsse, Cantó, Carey, Chen, Chong, Coggan, Crowe, Crowe, Cureton, Cuthbertson, D'Antona, Davis, Davis, Dominy, Dorta, Dulloo, Dulloo, Dumke, Egawa, Egawa, Eid, Fan, Ferketich, Fitts, Ganio, Gibala, Gliemann, Gollnick, Goodyear, Graham, Green, Gualano, Gutiérrez-Salmeán, Hagberg, Harms, Hasler, Hawley, Hawley, Hodgson, Holloszy, Holloszy, Holloszy, Hoppeler, Howitz, Hüttemann, Ingjer, Ivy, Jones, Jung, Kalliokoski, Karlsson, Klausen, Koivisto, Labayen, Lee, Liang, Lin, Little, Lluís, López-Lluch, MacMahon, Martínez-Redondo, Matsakas, Maughan, Merrill, Molé, Montero, Moore, Moore, Morris, Murase, Murase, Murias, Murias, Narkar, Nieman, Nogueira, Olesen, Oscai, Ota, Park, Perez-Schindler, Philp, Pogozelski, Puigserver, Putman, Raben, Randell, Randell, Richter, Sahebkar, Saleem, Saltin, Saltin, Saltin, Saltin, Sawka, Scribbans, Shimotoyodome, Siemann, Simoneau, Smith, Spangenburg, Spina, Spina, Steinberg, Suchankova, Sun, Venables, Wang, White, Winder, Wright, Wright, Yan, Youn, Zhu   +134 more
core   +5 more sources

Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function

Aging, 2020
Polyamines have been shown to delay cellular and organismal aging and to provide cardiovascular protection in humans. Because age-related cardiovascular dysfunction is often accompanied by impaired mitochondrial biogenesis and function, we explored the ...
Junying Wang, Shaoqi Li, Ju Wang, Feixiang Wu, Yuhan Chen, Hao Zhang, Yubo Guo, Yan Lin, Lingxu Li, Xue-Kuan Yu, Ting Liu, Yajun Zhao   +11 more
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast

Chinese Journal of Physiology, 2020
Glucocorticoid (GC)-induced bone loss is the most prevalent form of secondary osteoporosis. Previous studies demonstrated that long-term incubation of dexamethasone (DEX) induced oxidative stress and mitochondrial dysfunctions, consequently leading to ...
Chien-Ning Hsu, Chih-Yuan Jen, Yu-Hsu Chen, Shao-Yu Peng, Shinn-Chih Wu, Chao-Ling Yao   +5 more
doaj   +1 more source

FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway

Cell Communication and Signaling, 2023
Fibroblast growth factor 19 (FGF19) is recognized to play an essential role in cartilage development and physiology, and has emerged as a potential therapeutic target for skeletal metabolic diseases.
Shiyi Kan, Caixia Pi, Li Zhang, Daimo Guo, Zhixing Niu, Yang Liu, Mengmeng Duan, Xiahua Pu, Mingru Bai, Chenchen Zhou, Demao Zhang, Jing Xie   +11 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

miR449a/SIRT1/PGC-1α Is Necessary for Mitochondrial Biogenesis Induced by T-2 Toxin

Frontiers in Pharmacology, 2018
T-2 toxin is one of the type A trichothecenes produced mainly by the Fusarium genus. Due to its broad distribution and highly toxic nature, it is of great concern as a threat to human health and animal breeding.
Shijie Ma, Shijie Ma, Yurong Zhao, Yurong Zhao, Jianwei Sun, Peiqiang Mu, Peiqiang Mu, Yiqun Deng, Yiqun Deng   +8 more
doaj   +1 more source

Protein import into the endosymbiotic organelles of apicomplexan parasites [PDF]

, 2018
The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar
Fellows, Justin, Johnson, Carla, Mallo, Natalia, Sheiner, Lilach   +3 more
core   +1 more source

MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth

Signal Transduction and Targeted Therapy, 2020
Mitochondrial calcium uniporter (MCU) has an important role in regulating mitochondrial calcium (Ca 2+ ) homeostasis. Dysregulation of mitochondrial Ca 2+ homeostasis has been implicated in various cancers.
Yang Liu, Mingpeng Jin, Yaya Wang, Jianjun Zhu, Rui Tan, J. Zhao, Xiaoying Ji, Chao Jin, Yongfeng Jia, T. Ren, J. Xing   +10 more
semanticscholar   +1 more source