Results 81 to 90 of about 123,664 (300)

Nucleo‐mitochondrial interactions in yeast mitochondrial biogenesis [PDF]

European Journal of Biochemistry, 1989
For what once were probably free-living aerobic bacteria, mitochondria show a surprising degree of domestication in terms of their dependence on the genetic system of the cells in which they reside. In most organisms, only a handful of the hundred or so mitochondrial proteins are encoded by mitochondrial DNA (mtDNA).
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Stimulatory Effects of Balanced Deep Sea Water on Mitochondrial Biogenesis and Function. [PDF]

PLoS ONE, 2015
The worldwide prevalence of metabolic diseases, including obesity and diabetes, is increasing. Mitochondrial dysfunction is recognized as a core feature of these diseases.
Byung Geun Ha, Jung-Eun Park, Hyun-Jung Cho, Yun Hee Shon   +3 more
doaj   +1 more source

Mitochondrial Biogenesis in Kidney Disease [PDF]

Journal of the American Society of Nephrology, 2011
The transcriptional regulation of mitochondrial biogenesis by normal metabolic adaptation or injury has been clarified over the past decade. Mitochondrial biogenesis and its attendant processes enhance metabolic pathways such as fatty acid oxidation and increase antioxidant defense mechanisms that ameliorate injury from aging, tissue hypoxia, and ...
openaire   +2 more sources

Redox regulation of mitochondrial biogenesis [PDF]

Free Radical Biology and Medicine, 2012
The cell renews, adapts, or expands its mitochondrial population during episodes of cell damage or periods of intensified energy demand by the induction of mitochondrial biogenesis. This bigenomic program is modulated by redox-sensitive signals that respond to physiological nitric oxide (NO), carbon monoxide (CO), and mitochondrial reactive oxygen ...
Claude A, Piantadosi, Hagir B, Suliman
openaire   +2 more sources

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Induction of mitochondrial biogenesis enhances neurogenesis and cognitive recovery following ischaemic stroke

Anesthesiology and Perioperative Science
Purpose Stroke can cause severe cognitive impairment in patients. Recently, neurogenesis has been proposed as a potential approach to improve cognitive abilities after stroke.
Fuhai Bai, Zonghong Long, Jing Yang, Ping Liu, Zhuoxi Wu, Hongxu Chen, Youliang Deng, Min Ying, Shanshan Zhang, Jiaxin Li, Yanjuan Chen, Huizhong Wen, Min Zhang, Ying Xiong, Hong Li   +14 more
doaj   +1 more source

Transcriptional integration of mitochondrial biogenesis [PDF]

Trends in Endocrinology & Metabolism, 2012
Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the mitochondria to regulate the control of mitochondrial transcription, translation, and other functions.
Richard C, Scarpulla, Rick B, Vega, Daniel P, Kelly   +2 more
openaire   +2 more sources