Results 71 to 80 of about 123,664 (300)

Biogenesis of the mitochondrial Hsp70 chaperone [PDF]

Journal of Cell Biology, 2012
Chaperones mediate protein folding and prevent deleterious protein aggregation in the cell. However, little is known about the biogenesis of chaperones themselves. In this study, we report on the biogenesis of the yeast mitochondrial Hsp70 (mtHsp70) chaperone, which is essential for the functionality of mitochondria.
Blamowska, M., Neupert, W., Hell, K.
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity [PDF]

, 2013
There are hints of an altered mitochondrial function in obesity. Nuclear-encoded genes are relevant for mitochondrial function (3 gene sets of known relevant pathways: (1) 16 nuclear regulators of mitochondrial genes, (2) 91 genes for oxidative ...
Wichmann, Heinz-Erich, Martin Klingenspor, Knoll, Nadja, André Scherag, Jarick Ivonne, Hebebrand, J., Anna-Lena Volckmar, Gieger, C., Christian Gieger, Anna-Lena Volckmar (280948), Nadja Knoll (280947), Knoll, N., Christian Gieger (87555), Ivonne Jarick, Hebebrand, Johannes, Klingenspor Martin, Gieger Christian, Grallert, Harald, Wichmann, H.-E., Illig, T., Jarick, Ivonne, Volckmar, Anna-Lena, Wichmann Heinz-Erich, Peters, Annette, Illig Thomas, Ivonne Jarick (250179), Anke Hinney (87545), Johannes Hebebrand, Volckmar Anna-Lena, Peters Annette, Nadja Knoll, Annette Peters (62601), Heinz-Erich Wichmann, Scherag André, Annette Peters, Harald Grallert (72666), Thomas Illig (44906), Klingenspor, Martin, Peters, A., Illig, Thomas, Grallert Harald, Thomas Illig, Harald Grallert, Hebebrand Johannes, Johannes Hebebrand (170268), Gieger, Christian, Anke Hinney, Hinney Anke, Martin Klingenspor (68144), Scherag, André, Klingenspor, M., Grallert, H., Hinney, A., Hinney, Anke, Jarick, I., Volckmar, A.-L., André Scherag (170155), Heinz-Erich Wichmann (280949), Scherag, A., Knoll Nadja   +59 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Biogenesis of the mitochondrial phosphate carrier [PDF]

European Journal of Biochemistry, 1991
The mitochondrial phosphate carrier (PiC) is a member of the family of inner‐membrane carrier proteins which are generally synthesized without a cleavable presequence. Surprisingly, the cDNA sequences of bovine and rat PiC suggested the existence of an amino‐terminal extension sequence in the precursor of PiC.
ZARA, Vincenzo, RASSOW J, WACHTER E, TROPSCHUG M, PALMIERI F, NEUPERT W, PFANNER N.   +6 more
openaire   +5 more sources

Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis

, 2011
Purpose: Exercise increases the production of reactive oxygen species (ROS) in skeletal muscle, and athletes often consume antioxidant supplements in the belief they will attenuate ROS-related muscle damage and fatigue during exercise.
AYA MATSUMOTO, SUSAN A. MARSH, Matsumoto, Aya, JONATHAN M. PEAKE, JEFF S. COOMBES, Wadley, Glenn, GLENN D. WADLEY, Strobel, Natalie, Peake, Jonathan, Marsh, Susan, Coombes, Jeff S., NATALIE A. STROBEL   +11 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. [PDF]

PLoS ONE, 2012
By catabolizing glucose and lipids, mitochondria produce ATPs to meet energy demands. When the number and activity of mitochondria are not sufficient, the human body becomes easily fatigued due to the lack of ATP, thus the control of the quantity and ...
Hyun Woo Jeong, Si Young Cho, Shinae Kim, Eui Seok Shin, Jae Man Kim, Min Jeong Song, Pil Joon Park, Jong Hee Sohn, Hyon Park, Dae-Bang Seo, Wan Gi Kim, Sang-Jun Lee   +11 more
doaj   +1 more source

Electron Microscope Study Of Mitochondrial 60S and Cytoplasmic 80S Ribosomes From Locusta Migratoria [PDF]

, 1974
Purified mitochondrial ribosomes (60S) have been isolated from locust flight muscle. Purification could be achieved after lysis of mitochondria in 0.055 M MgCl2.
F. Miller, W. Neupert, Neupert, Walter, Miller, Fritz, Kleinow, W., W. Kleinow   +5 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source