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Mitochondrial genetic diseases [PDF]

open access: yesCurrent Opinion in Pediatrics, 2010
Mitochondrial diseases are individually uncommon, but collectively pose a significant burden on human health. Primary mitochondrial disease is caused by defects in the mitochondrial DNA-encoded genes or in nuclear genes whose products are imported into the mitochondrion.
Marni J, Falk, Neal, Sondheimer
openaire   +2 more sources

Mitochondria as a Target for Future Diabetes Treatments

open access: yesInternational Journal of Medical Students, 2015
Diabetes mellitus is rapidly becoming the world’s most dangerous serial killer. Type 1 diabetes (T1D) is a currently incurable autoimmune disease marked by progressive, and eventually exhaustive, destruction of the insulin-producing pancreatic beta cells.
Franziska Thimm, Marten Szibor
doaj   +3 more sources

Morning and evening exercise

open access: yesIntegrative Medicine Research, 2013
A growing body of evidence suggests that exercise may contribute to preventing pathological changes, treating multiple chronic diseases, and reducing mortality and morbidity ratios.
Dae Yun Seo   +6 more
doaj   +1 more source

Anesthetic considerations of Joubert syndrome in patients with mitochondrial disease - A case report - [PDF]

open access: yesAnesthesia and Pain Medicine, 2021
Background Joubert syndrome and mitochondrial disease are rare congenital diseases in which a wide range of symptoms affects multiple organs. Patients with these diseases present characteristic symptoms related to the musculoskeletal, respiratory, and ...
Jeong Yeon Kim   +5 more
doaj   +1 more source

Pu-18-N-butylimide-NMGA-GNP conjugate is effective against hepatocellular carcinoma

open access: yesIntegrative Medicine Research, 2013
Background: Photodynamic therapy (PDT) is a new modality in the treatment of cancer. This study thus aims to examine whether the PDT is effective against in vivo hepatocellular carcinoma.
Jin-Geun Kwon   +9 more
doaj   +1 more source

Acetylcholinesterase Inhibitory Activity of Pigment Echinochrome A from Sea Urchin Scaphechinus mirabilis

open access: yesMarine Drugs, 2014
Echinochrome A (EchA) is a dark-red pigment of the polyhydroxynaphthoquinone class isolated from sea urchin Scaphechinus mirabilis. Acetylcholinesterase (AChE) inhibitors are used in the treatment of various neuromuscular disorders, and are considered as
Sung Ryul Lee   +9 more
doaj   +1 more source

E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages

open access: yesBioengineering & Translational Medicine, 2021
Recent studies indicate that umbilical cord stem cells are cytoprotective against several disorders. One critical limitation in using stem cells is reduction in their viability under stressful conditions, such as diabetes.
Ayaz Ali   +9 more
doaj   +1 more source

Mitochondrial Disease [PDF]

open access: yesJournal of Child Neurology, 2014
Mitochondrial disease was chosen as the topic for the 13th Neurobiology of Disease in Children Symposium, held on October 31, 2013, in Austin, Texas. Program codirectors Drs Bruce Cohen and William Copeland prepared an engaging agenda that included individual presentations as well as a panel discussion from leaders working to advance the field of ...
Ben Thornton   +3 more
openaire   +2 more sources

Echinochrome A Protects Mitochondrial Function in Cardiomyocytes against Cardiotoxic Drugs

open access: yesMarine Drugs, 2014
Echinochrome A (Ech A) is a naphthoquinoid pigment from sea urchins that possesses antioxidant, antimicrobial, anti-inflammatory and chelating abilities.
Seung Hun Jeong   +10 more
doaj   +1 more source

Echinochrome A Increases Mitochondrial Mass and Function by Modulating Mitochondrial Biogenesis Regulatory Genes

open access: yesMarine Drugs, 2014
Echinochrome A (Ech A) is a natural pigment from sea urchins that has been reported to have antioxidant properties and a cardio protective effect against ischemia reperfusion injury.
Seung Hun Jeong   +11 more
doaj   +1 more source

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