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Searching for alternative toxicology testing systems: The response of isolated mitochondria from Saccharomyces cerevisiae, potato tuber, and mouse liver to a toxic insult [PDF]
Trends in Pharmaceutical Sciences, 2021 Mitochondria are cellular power plants known as essential organelles for energy (ATP) metabolism. However, today it is evident that various vital compounds are partially or exclusively synthesized in mitochondria. Moreover, this organelle plays a pivotal
Pouria Mobasher +5 more
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Marine Drugs, 2014 Echinochrome A (Ech A) is a natural pigment from sea urchins that has been reported to have antioxidant properties and a cardio protective effect against ischemia reperfusion injury.
Seung Hun Jeong +11 more
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Recent advances in understanding the molecular genetic basis of mitochondrial disease
Journal of Inherited Metabolic Disease, 2019 Mitochondrial disease is hugely diverse with respect to associated clinical presentations and underlying genetic causes, with pathogenic variants in over 300 disease genes currently described.
K. Thompson +9 more
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Mitochondrial disease in flies
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2004 The Drosophila mutant technical knockout (tko), affecting the mitochondrial protein synthetic apparatus, exhibits respiratory chain deficiency and a phenotype resembling various features of mitochondrial disease in humans (paralytic seizures, deafness, developmental retardation).
Kevin M.C. O'Dell +5 more
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Neuropathology of mitochondrial diseases
Bioscience Reports, 2007 The term “mitochondrial diseases” (MD) refers to a group of disorders related to respiratory chain dysfunction. Clinical features are usually extremely heterogeneous because MD may involve several tissues with different degrees of severity. Muscle and brain are mostly affected, probably because of their high dependence on oxidative metabolism.
FILOSTO M +7 more
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Drug Delivery, 2021 Nicotinamide riboside (NR), as a dietary supplement, can be converted to nicotinamide adenine dinucleotide (NAD+) in cells to support mitochondrial energy metabolism.
Hongfei Nie +5 more
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Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease
Scientific Reports, 2019 Leigh syndrome is a mitochondrial disease characterized by neurological disorders, metabolic abnormality and premature death. There is no cure for Leigh syndrome; therefore, new therapeutic targets are urgently needed. In Ndufs4-KO mice, a mouse model of
C. F. Lee +5 more
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Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2004 By convention, the term "mitochondrial diseases" refers to disorders of the mitochondrial respiratory chain, which is the only metabolic pathway in the cell that is under the dual control of the mitochondrial genome (mtDNA) and the nuclear genome (nDNA).
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease
Annals of Neurology, 2015 The prevalence of mitochondrial disease has proven difficult to establish, predominantly as a result of clinical and genetic heterogeneity. The phenotypic spectrum of mitochondrial disease has expanded significantly since the original reports that ...
G. Gorman +12 more
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Journal of Epilepsy Research, 1970 Mitochondria contain the respiratory chain enzyme complexes that carry out oxidative phosphorylation and produce the main part of cellular energy in the form of ATP. Although several proteins related with signalling, assembling, transporting, and enzymatic function can be impaired in mitochondrial diseases, most frequently the activity of the ...
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