Mitochondrial Dynamics in Mitochondrial Diseases
Diseases, 2016 Mitochondria are very versatile organelles in continuous fusion and fission processes in response to various cellular signals. Mitochondrial dynamics, including mitochondrial fission/fusion, movements and turnover, are essential for the mitochondrial ...
Juan M. Suárez-Rivero +9 more
doaj +5 more sources
A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases. [PDF]
Int J Mol Sci, 2022 Mitochondria are the main sites for oxidative phosphorylation and synthesis of adenosine triphosphate in cells, and are known as cellular power factories.
Chen B, Zhang W, Lin C, Zhang L.
europepmc +2 more sources
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases. [PDF]
Commun Biol, 2023 Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic basis for this clinical picture remains unclear.
Sturm G +28 more
europepmc +2 more sources
Mitochondrial Transplantation as a Novel Therapeutic Strategy for Mitochondrial Diseases
International Journal of Molecular Sciences, 2021 Mitochondria are the major source of intercellular bioenergy in the form of ATP. They are necessary for cell survival and play many essential roles such as maintaining calcium homeostasis, body temperature, regulation of metabolism and apoptosis ...
Anna Park +8 more
semanticscholar +1 more source
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing
Cell Discovery, 2021 Dear Editor, Mitochondrial diseases are a group of heterogeneous genetic disorders that are characterized by dysfunctional mitochondria and often manifest as severe even lethal condition.
Jiayin Guo +9 more
semanticscholar +1 more source
Mitochondria in neurogenesis: Implications for mitochondrial diseases
Stem Cells, 2021 Mitochondria are organelles with recognized key roles in cellular homeostasis, including bioenergetics, redox, calcium signaling, and cell death.
D. Brunetti +4 more
semanticscholar +1 more source
Antioxidants, 2022 We analyzed the effects of apoptosis-inducing factor (AIF) deficiency, as well as those of an exercise training intervention on autophagy across tissues (heart, skeletal muscle, cerebellum and brain), that are primarily affected by mitochondrial diseases,
Sara Laine-Menéndez +8 more
doaj +1 more source
Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism [PDF]
Diabetes & Metabolism Journal, 2020 Over a hundred billion bacteria are found in human intestines. This has emerged as an environmental factor in metabolic diseases, such as obesity and related diseases.
Yeonmi Lee, Hui-Young Lee
doaj +1 more source
Epilepsy in Mitochondrial Diseases—Current State of Knowledge on Aetiology and Treatment
Children, 2021 Mitochondrial diseases are a heterogeneous group of diseases resulting from energy deficit and reduced adenosine triphosphate (ATP) production due to impaired oxidative phosphorylation.
Dorota Wesół-Kucharska +2 more
semanticscholar +1 more source
The Power of Yeast in Modelling Human Nuclear Mutations Associated with Mitochondrial Diseases
Genes, 2021 The increasing application of next generation sequencing approaches to the analysis of human exome and whole genome data has enabled the identification of novel variants and new genes involved in mitochondrial diseases.
Camilla Ceccatelli Berti +6 more
semanticscholar +1 more source