Results 31 to 40 of about 507,433 (303)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Mitochondrial Dysfunction in Ageing and Diseases [PDF]

, 2016
The past decade has witnessed an explosion of knowledge regarding how mitochondrial dysfunction may translate into ageing and disease phenotypes, as well as how it is modulated by genetic and lifestyle factors.

core   +1 more source

Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

Molecular Neurodegeneration
Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD).
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth   +7 more
doaj   +1 more source

Gene expression in a drosophila model of mitochondrial disease [PDF]

, 2010
Background A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, was previously shown to cause a phenotype of respiratory chain deficiency, developmental delay, and neurological abnormalities similar to ...
Esko Kemppainen, Jacobs, H.T., Daniel J M Fernández-Ayala, Shanjun Chen, Fernandez-Ayala, Daniel JM, Kemppainen, E., Kevin M C O'Dell, O'Dell, Kevin MC, Jacobs, Howard T, Chen, S., Chen, Shanjun, Kemppainen, Esko, O'Dell, K.M.C., Kevin M. C. O'Dell, Howard T. Jacobs, Fernández-Ayala, D.J.M., Howard T Jacobs, Daniel J. M. Fernández-Ayala   +17 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Poor Outcome in a Mitochondrial Neurogastrointestinal Encephalomyopathy Patient with a Novel TYMP Mutation: The Need for Early Diagnosis. [PDF]

, 2012
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues and ...
Padovani Alessandro, SCARPELLI, Mauro, Anna Russignan, Padovani, A, PADOVANI, Alessandro, Bereczki, C, Paola Tonin, Bax Bridget E., Buono, R, Filosto Massimiliano, ZAPPINI, Francesca, Filosto M., Russignan, A, Bridget E. Bax, Alessandro Padovani, Zappini, F, Filosto, M, Bereczki Csaba, Bax, BE, Tonin, P, Massimiliano Filosto, Bax B. E., Padovani A., Zombor, M, Tonin Paola, Buono, Romina, Bereczki C., Zombor Melinda, Zombor M., Mauro Scarpelli, Romina Buono, Zappini Francesca, Scarpelli Mauro, Csaba Bereczki, Russignan Anna, Francesca Zappini, RUSSIGNAN, Anna, Buono Romina, TONIN, PAOLA, Melinda Zombor, Scarpelli, M   +40 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Queuine ameliorates impaired mitochondrial function caused by mt-tRNAAsn variants

Journal of Translational Medicine
Background Mitochondrial tRNA (mt-tRNA) variants have been found to cause disease. Post-transcriptional queuosine (Q) modifications of mt-tRNA can promote efficient mitochondrial mRNA translation.
Yan Lin, Jiayin Wang, Xingyu Zhuang, Ying Zhao, Wei Wang, Dongdong Wang, Yuying Zhao, Chuanzhu Yan, Kunqian Ji   +8 more
doaj   +1 more source

Reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy

, 2013
Direct evidence confirming the hypothesis that a dysfunction of the mitochondrial respiratory chain (MRC) underlies the pathogenesis of hyperlactatemia associated with highly active antiretroviral therapy (HAART) is scarce.
Miró Meda, José M. (José María), 1956-, Cardellach, Francesc, López Moreno, Sònia, Martínez, Esteban, Blanco, José L., Milinkovic, Ana, Rodríguez Santiago, Benjamín, Gatell, José M., Nunes Martínez, Virginia, Casademont i Pou, Jordi, Miró i Andreu, Òscar   +10 more
core   +1 more source