Results 51 to 60 of about 2,946,385 (264)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Pbk positively regulates myoblast differentiation and muscle regeneration via enhancing AMPK/ULK1 mediated myogenic autophagy

Journal of Translational Medicine
Background The activity of normal myoblasts is essential for the regeneration of skeletal muscle following injury. Nevertheless, the intrinsic mechanisms governing myoblast functions and muscle regeneration remain inadequately elucidated.
Dongdong Wang, Didi Shan, Dandan Zhao, Tingjun Dai, Fuchen Liu, Chuanzhu Yan   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Correction of aberrant splicing caused by intronic CAPN3 pathogenic variants using RNA-targeted therapeutic strategies in limb-girdle muscular dystrophy type R1

Orphanet Journal of Rare Diseases
Background Pre-mRNA splicing is a highly precise process, and it is estimated that approximately 9%–11% of pathogenic variants in patients with rare genetic diseases are caused by non-coding variants that disrupt this mechanism.
Gaoyuan Li, Yunuo Guo, Guangyu Wang, Haoyang Liu, Xiaoqing Lv, Pengfei Lin   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Establishment of THP-1 Monocytes with Compromised Mitochondrial Functions [PDF]

, 2009
The process of inflammation is important for both normal health and in a number of diseases, such as metabolic disorders, autoimmune diseases, and neurodegenerative diseases. Mitochondria are vital for the functioning of all cells. It had been implicated
Chou, Tzu-wen Joy
core  

Fatigue and exercise intolerance in mitochondrial diseases. Literature revision and experience of the Italian Network of mitochondrial diseases [PDF]

, 2012
Fatigue and exercise intolerance are common symptoms of mitochondrial diseases, but difficult to be clinically assessed. New methods to quantify these rather common complaints are strongly needed in the clinical practice.
Servidei, Serenella, SCARPELLI, Mauro, Angelini C, TOSCANO, ANNA, G. Uziel, Valentino, M. L., Comi G. P, Toscano, A., S. Servidei, C. Minetti, Minetti, C., Moroni, I., Mongini T, Siciliano G, E. Bertini, Bertini E, Bertini, E., Comi, G.P., ANGELINI, CRISTINA, T. Mongini, Santorelli, F. M., Zeviani M, Tonin, P., Comi GP, Servidei S, Spinazzi, M., Mancuso, M., M. Zeviani, G. Siciliano, M. Moggio, CARELLI, VALERIO, Toscano A, SICILIANO, GABRIELE, G.P. Comi, Zeviani, M., Angelini, C., Vercelli, L., Uziel G, V. Carelli, FILOSTO, Massimiliano, Siciliano G., Pegoraro, E., Nation wide Italian Collaborative Network of Mitochondrial Diseases, Moggio M, Lamperti, C., Mancuso M, Siciliano, G., Musumeci, O., Orsucci, D., M. Mancuso, Carelli, V., Martinelli, D., MANCUSO, MICHELANGELO, Collaborators: Bruno, C., Sciacco, M., Moggio, M., Comi, G. P., Minetti C, Uziel, G., Carelli V, Mongini, T., Servidei, S., TONIN, PAOLA, MINETTI, CARLO, Tonin P, P. Tonin   +65 more
core   +1 more source

The Interplay between Mitochondrial Dysfunction and Ferroptosis during Ischemia-Associated Central Nervous System Diseases

, 2023
Cerebral ischemia, a leading cause of disability and mortality worldwide, triggers a cascade of molecular and cellular pathologies linked to several central nervous system (CNS) disorders.
Xiang-Yu Chen, Jin-Wen Ge, Yue Zhou, He-Yan Tian, Zhi-Gang Mei, Tong Yang, Shao-Wu Cheng, Bo-Yang Huang, Hui-Fang Nie   +8 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source