Results 21 to 30 of about 742,356 (291)
Frontiers in Physiology, 2020 AimCerebellar neurodegeneration is a main phenotypic manifestation of mitochondrial disorders caused by apoptosis-inducing factor (AIF) deficiency. We assessed the effects of an exercise training intervention at the cerebellum and brain level in a mouse ...
Miguel Fernández-de la Torre +12 more
doaj +1 more source
Scientific Reports, 2021 Simulated hypobaric hypoxia (SHH) training has been used to enhance running performance. However, no studies have evaluated the effects of a single SHH exposure on healthy mice performance and analyzed the changes of mitochondria-related genes in the ...
Fei-Fei Wu +9 more
doaj +1 more source
Nature Communications, 2019 Cytochrome P450 oxidases (CYPs) are enzymes that participate in the xenobiotic detoxification and their expression is enhanced in long-lived model organisms.
Marija Herholz +9 more
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Physical Exercise and Mitochondrial Disease: Insights From a Mouse Model
Frontiers in Neurology, 2019 Purpose: Mitochondrial diseases (MD) are among the most prevalent neuromuscular disorders. Unfortunately, no curative treatment is yet available. This study analyzed the effects of exercise training in an animal model of respiratory chain complex I ...
Carmen Fiuza-Luces +13 more
doaj +1 more source
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
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Scientific Reports, 2017 Mitochondrial diseases due to mutations in the mitochondrial (mt) DNA are heterogeneous in clinical manifestations but usually include OXPHOS dysfunction. Mechanisms by which OXPHOS dysfunction contributes to the disease phenotype invoke, apart from cell
Salvador Meseguer +8 more
doaj +1 more source
Fingolimod phosphate protection against mitochondrial damage in neuronal cells [PDF]
, 2019 Background: Major role of oxidative stress in the pathogenesis of neurodegenerative diseases have been suggested, being mitochondria one of the main sources of ROS. Aim: In the present work, we have studied the antioxidant effect of fingolimod phosphate
Alvarez-Gil, Antonio +8 more
core +1 more source
Journal of Child Neurology, 2014 Mitochondrial disease was chosen as the topic for the 13th Neurobiology of Disease in Children Symposium, held on October 31, 2013, in Austin, Texas. Program codirectors Drs Bruce Cohen and William Copeland prepared an engaging agenda that included individual presentations as well as a panel discussion from leaders working to advance the field of ...
Ben Thornton +3 more
openaire +2 more sources
EMBO Molecular Medicine, 2018 The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm, and cellular models of mitochondrial disease, via an unclear mechanism.
Gabriele Civiletto +8 more
doaj +1 more source
Mitochondrial Dysfunction in Aging and Diseases of Aging. [PDF]
, 2019 Mitochondria have been increasingly recognized as the important players in the aging process [...]
Haas, Richard H
core +2 more sources