Results 131 to 140 of about 483,484 (261)

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Evaluating a Coenzyme Q10-Based Food for Special Medical Purpose, for Mitochondrial Diseases Management: An Open-Label, Pilot Trial. [PDF]

Int J Mol Sci
Chico L, Lopriore P, Cecchi G, Meli A, Bernardini C, Balestrini L, Polzella M, Montano V, Mancuso M.   +8 more
europepmc   +1 more source

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

Advanced Healthcare Materials, EarlyView.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen, Nina Li, Meiyan Zou, Zihao Zhou, Rongwei Xu, Weiyao Feng, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source

Mitochondrial Diseases: Molecular Pathogenesis and Therapeutic Advances. [PDF]

MedComm (2020)
Mei J, Ding P, Gao C, Zhou J, Li Z, Zhang C, Gao J.   +6 more
europepmc   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

ATAD3 duplications bridge mitochondrial diseases and Aicardi-Goutières syndrome. [PDF]

Dev Med Child Neurol
Planté-Bordeneuve P, Bérat CM, Hanein S, Gitiaux C, ATAD3 Study Group, Steffann J, Desguerre I, Rötig A, Boddaert N, Barcia G.   +9 more
europepmc   +1 more source

The Effect of Photobiomodulation on the Treatment of Hereditary Mitochondrial Diseases. [PDF]

J Lasers Med Sci, 2023
Baskerville R, Krijgsveld N, Esser P, Jeffery G, Poulton J.   +4 more
europepmc   +1 more source

Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function

Advanced Healthcare Materials, EarlyView.
Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo, Wing Tai Tung, Harvey Lewis, Kavin Hettiarachchilage, Babis Tzivelekis, Rolando Berlinguer‐Palmini, Ana Marina Ferreira, Jason Gill, Kenneth Dalgarno   +8 more
wiley   +1 more source

No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. [PDF]

Eur J Immunol
Marchais M, Pennisi A, Pierga A, Lepelley A, Cagnard N, Bole C, Nitschke P, Hamici M, Rieux-Laucat F, Schiff M, Munnich A, Rötig A.   +11 more
europepmc   +1 more source

Red Flags in Primary Mitochondrial Diseases: What Should We Recognize? [PDF]

Int J Mol Sci, 2023
Conti F, Di Martino S, Drago F, Bucolo C, Micale V, Montano V, Siciliano G, Mancuso M, Lopriore P.   +8 more
europepmc   +1 more source