Results 11 to 20 of about 10,435,022 (365)

Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing

Cell Discovery, 2021
Dear Editor, Mitochondrial diseases are a group of heterogeneous genetic disorders that are characterized by dysfunctional mitochondria and often manifest as severe even lethal condition.
Jiayin Guo, Xue Zhang, Xiaoxu Chen, Haiyan Sun, Yichen Dai, Jianying Wang, Xuezhen Qian, Lei Tan, Xin Lou, Bin Shen   +9 more
semanticscholar   +1 more source

Apoptosis-Inducing Factor Deficiency Induces Tissue-Specific Alterations in Autophagy: Insights from a Preclinical Model of Mitochondrial Disease and Exercise Training Effects

Antioxidants, 2022
We analyzed the effects of apoptosis-inducing factor (AIF) deficiency, as well as those of an exercise training intervention on autophagy across tissues (heart, skeletal muscle, cerebellum and brain), that are primarily affected by mitochondrial diseases,
Sara Laine-Menéndez, Miguel Fernández-de la Torre, Carmen Fiuza-Luces, Aitor Delmiro, Joaquín Arenas, Miguel Ángel Martín, Patricia Boya, Alejandro Lucia, María Morán   +8 more
doaj   +1 more source

Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism [PDF]

Diabetes & Metabolism Journal, 2020
Over a hundred billion bacteria are found in human intestines. This has emerged as an environmental factor in metabolic diseases, such as obesity and related diseases.
Yeonmi Lee, Hui-Young Lee
doaj   +1 more source

Mitochondrial Unfolded Protein Response and Integrated Stress Response as Promising Therapeutic Targets for Mitochondrial Diseases

Cells, 2022
The development and application of high-throughput omics technologies have enabled a more in-depth understanding of mitochondrial biosynthesis metabolism and the pathogenesis of mitochondrial diseases.
Hedong Lu, Xiaolei Wang, Min Li, Dongmei Ji, Dan Liang, Chunmei Liang, Ya-Jing Liu, Zhiguo Zhang, Yu Cao, Weiwei Zou   +9 more
semanticscholar   +1 more source

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

International Journal of Molecular Sciences, 2022
Mitochondria are the main sites for oxidative phosphorylation and synthesis of adenosine triphosphate in cells, and are known as cellular power factories.
Baoyi Chen, Wenting Zhang, Chuyu Lin, Lingyun Zhang   +3 more
semanticscholar   +1 more source

Mitochondria in neurogenesis: Implications for mitochondrial diseases

Stem Cells, 2021
Mitochondria are organelles with recognized key roles in cellular homeostasis, including bioenergetics, redox, calcium signaling, and cell death.
D. Brunetti, Werner Dykstra, Stéphanie Le, Annika Zink, A. Prigione   +4 more
semanticscholar   +1 more source

Renal Phenotype in Mitochondrial Diseases: A Multicenter Study

Kidney Diseases, 2022
Aims: This study aimed to investigate associations between renal and extrarenal manifestations of mitochondrial diseases and their natural history as well as predictors of renal disease severity and overall disease outcome.
M. Parasyri, P. Brandström, J. Uusimaa, E. Ostergaard, Omar Hikmat, P. Isohanni, Karin Naess, I. D. de Coo, Andrés Nascimento Osorio, M. Nuutinen, C. Lindberg, L. A. Bindoff, M. Tulinius, N. Darín, K. Sofou   +14 more
semanticscholar   +1 more source

Epilepsy in Mitochondrial Diseases—Current State of Knowledge on Aetiology and Treatment

Children, 2021
Mitochondrial diseases are a heterogeneous group of diseases resulting from energy deficit and reduced adenosine triphosphate (ATP) production due to impaired oxidative phosphorylation.
Dorota Wesół-Kucharska, D. Rokicki, A. Jezela-Stanek   +2 more
semanticscholar   +1 more source

The Power of Yeast in Modelling Human Nuclear Mutations Associated with Mitochondrial Diseases

Genes, 2021
The increasing application of next generation sequencing approaches to the analysis of human exome and whole genome data has enabled the identification of novel variants and new genes involved in mitochondrial diseases.
Camilla Ceccatelli Berti, Giulia di Punzio, C. Dallabona, E. Baruffini, P. Goffrini, T. Lodi, C. Donnini   +6 more
semanticscholar   +1 more source

Sleep Disorders in Mitochondrial Diseases

Current Neurology and Neuroscience Reports, 2021
Purpose of Review We aim to summarize the sleep disorders reported in patients affected by primary mitochondrial dysfunctions and describe the association with their clinical and molecular characteristics.
V. Brunetti, G. Della Marca, S. Servidei, G. Primiano   +3 more
semanticscholar   +1 more source