Results 61 to 70 of about 10,033,806 (381)
Molecular NeurodegenerationBackground Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD).
Aitor Martinez +7 more
doaj +1 more source
Mitochondrial Biogenesis: Pharmacological Approaches [PDF]
, 2014 yesOrganelle biogenesis is concomitant to organelle inheritance during cell division. It is necessary that organelles double their size and divide to give rise to two identical daughter cells. Mitochondrial biogenesis occurs by growth and division of pre-
Valero-Grinan, Teresa M.
core +1 more source
Emerging therapies for mitochondrial diseases.
Essays in Biochemistry, 2018 For the vast majority of patients with mitochondrial diseases, only supportive and symptomatic therapies are available. However, in the last decade, due to extraordinary advances in defining the causes and pathomechanisms of these diverse disorders, new ...
M. Hirano, V. Emmanuele, C. Quinzii
semanticscholar +1 more source
Mitochondrial diseases and epilepsy [PDF]
Epilepsia, 2012 SummaryThe mitochondrial respiratory chain is the final common pathway for energy production. Defects affecting this pathway can give rise to disease that presents at any age and affects any tissue. However, irrespective of genetic defect, epilepsy is common and there is a significant risk of status epilepticus.
Bernt A. Engelsen, Laurence A. Bindoff
openaire +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Experimental and Molecular Medicine, 2019 Liver disease: Beneficial bacteria divert dietary fats Intestinal bacteria that consume common fatty acids could help protect their hosts against non-alcoholic fatty liver disease (NAFLD).
Hye Rim Jang +7 more
doaj +1 more source
Antioxidants, 2022 Intrauterine growth restriction (IUGR) affects 5–10% of newborns and increases the risks of intrauterine demise, neonatal morbidity, and death. In their recent publication, Yeste et al.
Glòria Garrabou +11 more
doaj +1 more source
Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. [PDF]
, 2015 ATP is essential for cellular function and is usually produced through oxidative phosphorylation. However, mitochondrial dysfunction is now being recognized as an important contributing factor in the development cardiovascular diseases, such as pulmonary
Black, Stephen M +8 more
core +1 more source
Mitochondrial disease and epilepsy [PDF]
Developmental Medicine & Child Neurology, 2012 Mitochondrial respiratory chain disorders are relatively common inborn errors of energy metabolism, with a combined prevalence of one in 5000. These disorders typically affect tissues with high energy requirements, and cerebral involvement occurs frequently in childhood, often manifesting in seizures.
openaire +4 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source