Results 161 to 170 of about 159,415 (265)

Unraveling the molecular determinants of a rare human mitochondrial disorder caused by the P144L mutation of FDX2. [PDF]

Protein Sci
Grifagni D, Doni D, Susini B, Fonseca BM, Louro RO, Costantini P, Ciofi-Baffoni S.   +6 more
europepmc   +1 more source

Camptocormia and Other Orthopedic Compromise Dominating Mitochondrial Disorder: A Case Report. [PDF]

Cureus, 2020
Finsterer J, Chatterjee S, Ghosh R.
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Author Correction: Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder. [PDF]

Cell Death Dis
Zhang X, Zhang B, Zhang C, Sun G, Sun X.
europepmc   +1 more source

Defining the nuclear genetic architecture of a common maternally inherited mitochondrial disorder

, 2022
Boggan RM, Ng YS, Franklin IG, Alston CL, Blakely EL, Büchner B, Bugiardini E, Colclough K, Feeney C, Hanna MG, Hattersley AT, Klopstock T, Kornblum C, Mancuso M, Patel KA, Pitceathly RDS, Pizzamiglio C, Prokisch H, Schäfer J, Schaefer AM, Shepherd MH, Thaele A, Thomas RH, Turnbull DM, Woodward CE, Gorman GS, McFarland R, Taylor RW, Cordell HJ, Pickett SJ.   +29 more
europepmc   +1 more source

POLG1-related Mitochondrial Disorder with MNGIE- and Leigh-like Features. [PDF]

Ann Indian Acad Neurol, 2020
Finsterer J.
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder. [PDF]

Invest Ophthalmol Vis Sci
Jurkute N, Brennenstuhl H, Kustermann M, Van Haute L, Mutti CD, Bugiardini E, Handa T, Shimura M, Petzold A, Acheson J, Robson AG, Macken WL, Hanna MG, Pitceathly RDS, Merve A, Kotzaeridou U, Kölker S, Freilinger M, Erdler M, Bittner RE, Mayr JA, Okazaki Y, Murayama K, Prokisch H, Webster AR, Minczuk M, Arno G, Pemp B, Hoffmann GF, Schmidt WM, Yu-Wai-Man P.   +30 more
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Reconsidering critical illness as an uncharacterised acquired mitochondrial disorder. [PDF]

J Intensive Care Soc, 2020
McKenna HT, Murray AJ.
europepmc   +1 more source