Results 201 to 210 of about 160,746 (308)

The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder

Ying He,1,* Xinbo Yang,1,* Zongchang Li,1 Weiqing Liu,2,3 Jinsong Tang,4 Xiaogang Chen1 1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of ...
Yang X, Tang J, Li Z, He Y, Chen X, Liu W   +5 more
core  

Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects

, 2015
Lilach Toker,1 Galila Agam2,3 1Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; 2Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 3Mental Health Center, Beer ...
Toker L, Agam G
core  

Author Correction: Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder. [PDF]

Cell Death Dis
Zhang X, Zhang B, Zhang C, Sun G, Sun X.
europepmc   +1 more source

Defining the nuclear genetic architecture of a common maternally inherited mitochondrial disorder

, 2022
Boggan RM, Ng YS, Franklin IG, Alston CL, Blakely EL, Büchner B, Bugiardini E, Colclough K, Feeney C, Hanna MG, Hattersley AT, Klopstock T, Kornblum C, Mancuso M, Patel KA, Pitceathly RDS, Pizzamiglio C, Prokisch H, Schäfer J, Schaefer AM, Shepherd MH, Thaele A, Thomas RH, Turnbull DM, Woodward CE, Gorman GS, McFarland R, Taylor RW, Cordell HJ, Pickett SJ.   +29 more
europepmc   +1 more source

POLG1-related Mitochondrial Disorder with MNGIE- and Leigh-like Features. [PDF]

Ann Indian Acad Neurol, 2020
Finsterer J.
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder. [PDF]

Invest Ophthalmol Vis Sci
Jurkute N, Brennenstuhl H, Kustermann M, Van Haute L, Mutti CD, Bugiardini E, Handa T, Shimura M, Petzold A, Acheson J, Robson AG, Macken WL, Hanna MG, Pitceathly RDS, Merve A, Kotzaeridou U, Kölker S, Freilinger M, Erdler M, Bittner RE, Mayr JA, Okazaki Y, Murayama K, Prokisch H, Webster AR, Minczuk M, Arno G, Pemp B, Hoffmann GF, Schmidt WM, Yu-Wai-Man P.   +30 more
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Auditory Brainstem Response in a Child with Mitochondrial Disorder-Leigh Syndrome. [PDF]

Indian J Otolaryngol Head Neck Surg
Pooja PS, Greeshma R, Joy EK, Swamy SP.
europepmc   +1 more source