Tertiary Structure and Function of Closed-Circular Mitochondrial DNA and Its Transcription in vivo [PDF]
Anil K. Rastogi+2 more
openalex +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han+9 more
wiley +1 more source
Selective In vivo damage by ‘visible’ light of brdu-containing mitochondrial dna in a thymidine kinase-deficient mouse cell line with persistent mitochondrial enzyme activity [PDF]
Bernard Croizat, Giuseppe Attardi
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Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu+14 more
wiley +1 more source
Stimulation of mitochondrial DNA synthesis as an early function of herpes simplex virus [PDF]
K. Radsak
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FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang+14 more
wiley +1 more source
A compact form of rat liver mitochondrial DNA stabilized by bound proteins.
Glenn C. Van Tuyle, M L McPherson
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Enzymatic synthesis of DNA complementary to mitochondrial mRNA via reverse transcription [PDF]
L.Yu. Frolova+6 more
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Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang+16 more
wiley +1 more source