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Ribonucleotide incorporation into mitochondrial DNA drives inflammation. [PDF]

Nature
Bahat A, Milenkovic D, Cors E, Barnett M, Niftullayev S, Katsalifis A, Schwill M, Kirschner P, MacVicar T, Giavalisco P, Jenninger L, Clausen AR, Paupe V, Prudent J, Larsson NG, Rogg M, Schell C, Muylaert I, Larsson E, Nolte H, Falkenberg M, Langer T.   +21 more
europepmc   +1 more source

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Mitochondrial DNA and aging

Clinical Science, 2004
Among the numerous theories that explain the process of aging, the mitochondrial theory of aging has received the most attention. This theory states that electrons leaking from the ETC (electron transfer chain) reduce molecular oxygen to form O2•− (superoxide anion radicals).
Mikhail F, Alexeyev, Susan P, Ledoux, Glenn L, Wilson   +2 more
openaire   +2 more sources

Transcription of Mitochondrial DNA

Critical Reviews in Biochemistry, 1983
While mitochondrial DNA (mtDNA) is the simplest DNA in nature, coding for rRNAs and tRNAs, results of DNA sequence, and transcript analysis have demonstrated that both the synthesis and processing of mitochondrial RNAs involve remarkably intricate events.
H. F. Tabak, L. A. Grivell, P. Borst, Giuseppe Attardi   +3 more
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Mitochondrial DNA in Tumors

Toxicology Mechanisms and Methods, 2004
Mitochondria, cellular powerhouses, play a central role in apoptosis. In addition, they are suspected to contribute to aging. There is also increasing evidence that abnormalities in mitochondrial function help cancer development. Changes in mitochondrial transcription and oxidative phosphorylation pathways are observed in many types of cancer.
Anna, Lorenc, Jaroslaw, Bryk, Ewa, Bartnik   +2 more
openaire   +2 more sources

DISEASES OF THE MITOCHONDRIAL DNA

Annual Review of Biochemistry, 1992
INTRODUCTION . . _ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 175 THE HUMAN MITOCHONDRIAL DNA AND OXIDATIVE PHOSPHORYLATION 1176 Mitochondrial Biogenesis ... 1 176 Mitochondrial OXPHOS Complexes and their Synthesis 1 178 Developmental Regulation of Nuclear OXPHOS Genes ...
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