Results 171 to 180 of about 254,248 (207)

Mitochondrial fission and fusion

Biochemical Society Transactions, 2016
Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes.
Hakjoo, Lee, Yisang, Yoon
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Mitochondrial fission and fusion

Biochemistry (Moscow), 2015
Mitochondria are key cellular organelles responsible for many different functions. The molecular biology of mitochondria is continuously subject to comprehensive studies. However, detailed mechanisms of mitochondrial biogenesis are still unclear. Fusion and fission are among the most enigmatic processes connected with mitochondria.
M V, Patrushev, I O, Mazunin, E N, Vinogradova, P A, Kamenski   +3 more
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Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Nature Chemical Biology, 2023
Membrane dynamics are important to the integrity and function of mitochondria. Defective mitochondrial fusion underlies the pathogenesis of multiple diseases. The ability to target fusion highlights the potential to fight life-threatening conditions.
Yingjie Guo, Huan Zhang, Chen Yan, Birong Shen, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, He Lv, Zhaoxia Wang, Yun Yuan, Jie-Feng Yang, Ya-Ting Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiaojiang Hao, Junjie Hu, Quan Chen   +28 more
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Physiological functions of mitochondrial fusion

Annals of the New York Academy of Sciences, 2010
In recent years, the dynamic nature of mitochondria has been discovered to be critical for their function. Here we discuss the molecular basis of mitochondrial fusion, its protective role in neurodegeneration, and its importance in cellular function. The mitofusins Mfn1 and Mfn2, GTPases localized to the outer membrane, mediate outer‐membrane fusion ...
Chen, Hsiuchen, Chan, David C.
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Mitochondrial Fusion In Vitro

2007
The field of mitochondrial dynamics has received a great deal of attention as a result of a number of studies linking mitochondrial fission and fusion machinery to apoptosis. Specifically, elevated levels of mitochondrial fission or compromised mitochondrial fusion can sensitize cells to apoptotic stimuli.
Shelly L, Meeusen, Jodi, Nunnari
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New Beginnings: Mitochondrial Renewal by Massive Mitochondrial Fusion

Trends in Plant Science, 2017
Massive mitochondrial fusion (MMF) in germinating arabidopsis seeds, together with earlier studies, suggests a significant role for MMF in the life cycle of flowering plants. MMF is likely to facilitate nucleoid transmission, mitochondrial DNA (mtDNA) recombination, and the homogenization of mitochondrial components, thus providing a type of quality ...
Ray J, Rose, David W, McCurdy
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Mitochondrial fusion and inheritance of the mitochondrial genome

Journal of Plant Research, 2010
Although maternal or uniparental inheritance of mitochondrial genomes is a general rule, biparental inheritance is sometimes observed in protists and fungi,including yeasts. In yeast, recombination occurs between the mitochondrial genomes inherited from both parents.Mitochondrial fusion observed in yeast zygotes is thought to set up a space for DNA ...
Hiroyoshi, Takano, Kenta, Onoue, Shigeyuki, Kawano   +2 more
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Mitochondrial Fusion Through Membrane Automata

2014
Studies have shown that malfunctions in mitochondrial processes can be blamed for diseases. However, the mechanism behind these operations is yet not sufficiently clear. In this work we present a novel approach to describe a biomolecular model for mitochondrial fusion using notions from the membrane computing.
Konstantinos, Giannakis, Theodore, Andronikos   +1 more
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Intersection between Mitochondrial Permeability Pores and Mitochondrial Fusion/Fission

Neurochemical Research, 2007
The goal of this review is to highlight recent developments in the field of mitochondrial membrane processes, which provide new insights into the relation between mitochondrial fission/fusion events and the mitochondrial permeability transition (MPT).
Irina G, Gazaryan, Abraham M, Brown
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Mitochondrial Fusion Intermediates Revealed in Vitro

Science, 2004
The events that occur during the fusion of double-membraned mitochondria are unknown. As an essential step toward determining the mechanism of mitochondrial fusion, we have captured this event in vitro. Mitochondrial outer and inner membrane fusion events were separable and mechanistically distinct, but both required guanosine 5′-triphosphate ...
Shelly, Meeusen, J Michael, McCaffery, Jodi, Nunnari   +2 more
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