Results 81 to 90 of about 528,538 (308)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Characterization and phylogenetic analysis of the complete mitochondrial genome of Clavulina sp. (Cantharellales: Clavulinaceae)

Mitochondrial DNA. Part B. Resources, 2020
In this study, the complete mitochondrial genome of Clavulina sp. was sequenced and assembled. The complete mitochondrial genome of Clavulina sp. contains 20 protein-coding (PCG) genes, 2 ribosomal RNA (rRNA) genes, and 25 transfer RNA (tRNA) genes.
Maoling Tan, Gang Zhao
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Role of the Mitochondrial Genome During Early Development in Mice [PDF]

, 1973
The role of the mitochondrial genome in early development and differentiation was studied in mouse embryos cultured in vitro from the two to four cell stage to the blastocyst (about 100 cells).
Chase, David G., Pikó, Lajos
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

MitoIMP: A Computational Framework for Imputation of Missing Data in Low-Coverage Human Mitochondrial Genome

Bioinformatics and Biology Insights, 2019
The incompleteness of partial human mitochondrial genome sequences makes it difficult to perform relevant comparisons among multiple resources. To deal with this issue, we propose a computational framework for deducing missing nucleotides in the human ...
Koji Ishiya, Fuzuki Mizuno, Li Wang, Shintaroh Ueda   +3 more
doaj   +1 more source

Phylogeny of Prokaryotes and Chloroplasts Revealed by a Simple Composition Approach on All Protein Sequences from Complete Genomes Without Sequence Alignment [PDF]

, 2005
The complete genomes of living organisms have provided much information on their phylogenetic relationships. Similarly, the complete genomes of chloroplasts have helped to resolve the evolution of this organelle in photosynthetic eukaryotes.
C Lemieux, CR Woese, CR Woese, D Sankoff, DH Moreira, E Chatton, E Mayr, E Pennisi, F Tekaia, FitchWM, GI McFadden, GI McFadden, GW Stuart, GW Stuart, J Adachi, J Las Rivas De, J Lin, J Qi, J Qi, J.Q. Deng, JA Eisen, JD Palmer, JR Brown, K.H. Chu, KH Chu, L.Q. Zhou, M Li, M Turmel, M Turmel, MA Ragan, MW Gray, MW Gray, N Saitou, O Weiss, RF Doolittle, RF Doolittle, RL Charlebois, RS Gupta, S.C. Long, ST Fitz-Gibbon, SV Edwards, V.V. Anh, VL Stirewalt, W Martin, W Martin, W Martin, Z.G. Yu, ZG Yu, ZG Yu, ZG Yu, ZG Yu   +50 more
core   +3 more sources

Pomegranate mitochondrial genome

, 2022
Punica granatum mitochondrial ...
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Echinococcus canadensis (G7) genome: A key knowledge of parasitic platyhelminth human diseases [PDF]

, 2017
Background: The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents of echinococcosis. Echinococcosis is a worldwide chronic zoonosis affecting humans as well as domestic and wild mammals, which ...
A Bankevich, A Gurevich, A Lomsadze, A Lomsadze, Adolfo Fox, AM Bolger, Anna C. M. Salim, B Hendrich, B Langmead, C Bermudez-Santana, C Hahn, C Holt, C Jiang, C Trapnell, CA Alvarez Rojas, CCM Budke, D Kim, D Takai, DP McManus, DR Zerbino, E Elkayam, E Keibler, E Quevillon, F Jeanmougin, F Kiefer, F Mohn, Federico Camicia, Flávio M. Gomes Araújo, G Abrusán, G Parra, GSC Slater, Guilherme Oliveira, H Li, H Zheng, I Korf, IJ Tsai, IJ Tsai, J Eckert, JK Nono, JM Bart, JP Hewitson, Juliana Assis, K Arnold, K Matsuo, K Thivierge, K Wasik, KJ Fryxell, KK Geyer, KK Geyer, L Han, L Han, L Kamenetzky, L Kamenetzky, L Kamenetzky, L Li, LA Kelley, Laura Kamenetzky, LD Moore, Lucas L. Maldonado, M Ashburner, M Biasini, M Cucher, M Cucher, M Krzywinski, M Marín, M Nakao, M Nakao, M Nakao, M Nakao, M Nakao, M Rosenzvit, M Sajid, M Stanke, MA Cucher, Mara Rosenzvit, Marcela Cucher, MC Rosenzvit, MW Robinson, N Guex, N Macchiaroli, N Schürmann, Natalia Macchiaroli, ND Young, O Bogdanović, P Carninci, P Cingolani, P Danecek, PM Muzulin, PM Schantz, PS Craig, R Luo, R Schneider, RD Finn, RJ Klose, S Assefa, S Maillard, S Saxonov, S Yi, SF Altschul, SM Sadjjadi, TD Otto, TD Otto, TM Lowe, U Koziol, U Saarma, W Pan, Y Moriya, Y Safonova, YA Medvedeva, Z Zhao   +109 more
core   +8 more sources