Results 81 to 90 of about 1,817,069 (382)

Early-stage idiopathic Parkinson’s disease is associated with reduced circular RNA expression

npj Parkinson's Disease
Neurodegeneration in Parkinson’s disease (PD) precedes diagnosis by years. Early neurodegeneration may be reflected in RNA levels and measurable as a biomarker. Here, we present the largest quantification of whole blood linear and circular RNAs (circRNA)
Benjamin J. Whittle, Osagie G. Izuogu, Hannah Lowes, Dasha Deen, Angela Pyle, Jon Coxhead, Rachael A. Lawson, Alison J. Yarnall, Michael S. Jackson, Mauro Santibanez-Koref, Gavin Hudson   +10 more
doaj   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

The Development of Mitochondrial Gene Editing Tools and Their Possible Roles in Crop Improvement for Future Agriculture

Advanced Genetics, 2022
We are living in the era of genome editing. Nowadays, targeted editing of the plant nuclear DNA is prevalent in basic biological research and crop improvement since its first establishment a decade ago.
Jinghua Yang, Xiaodong Yang, Tongbing Su, Zhongyuan Hu, Mingfang Zhang   +4 more
doaj   +1 more source

Mitochondrial genomes as living ‘fossils’ [PDF]

BMC Biology, 2013
The huge variation between mitochondrial genomes makes untangling their evolutionary histories difficult. Richardson et al. report on the remarkably unaltered 'fossil' genome of the tulip tree, giving us many clues as to how the mitochondrial genomes of flowering plants have evolved over the last 150 million years, and raising questions about how such ...
openaire   +2 more sources

The identification of mitochondrial DNA variants in glioblastoma multiforme [PDF]

, 2014
Background: Mitochondrial DNA (mtDNA) encodes key proteins of the electron transfer chain (ETC), which produces ATP through oxidative phosphorylation (OXPHOS) and is essential for cells to perform specialised functions.
Dickinson, Adam, Donoghue, J. F., Grammatopoulos, Dimitris K., Johnson, T. J., McKenzie, Matthew, Polekhina, G., St John, J. C., White, S. J., Yeung, Ka Yu   +8 more
core   +3 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Plant Mitochondrial Genome Evolution and Cytoplasmic Male Sterility

, 2017
Mitochondria are responsible for providing energy currency to life processes in the molecular form of ATP and are therefore typically referred to as the power factories of cells.
Zhiwen Chen, Nan Zhao, Shuang-shuang Li, C. Grover, Hushuai Nie, J. Wendel, J. Hua   +6 more
semanticscholar   +1 more source

Structure and variation of the mitochondrial genome of fishes

BMC Genomics, 2016
The mitochondrial (mt) genome has been used as an effective tool for phylogenetic and population genetic analyses in vertebrates. However, the structure and variability of the vertebrate mt genome are not well understood.
Takashi P. Satoh, M. Miya, K. Mabuchi, M. Nishida   +3 more
semanticscholar   +1 more source

The Mitochondrial Genome of Baylisascaris procyonis

PLoS ONE, 2011
Baylisascaris procyonis (Nematoda: Ascaridida), an intestinal nematode of raccoons, is emerging as an important helminthic zoonosis due to serious or fatal larval migrans in animals and humans. Despite its significant veterinary and public health impact, the epidemiology, molecular ecology and population genetics of this parasite remain largely ...
Jiabo Deng, Yue Xie, Xiaobin Gu, Guangyou Yang, Ning Yan, Deying Yang, Jingchao Lan, Guiying Hao, Zhihe Zhang, Huaming Nie, Xuerong Peng, Yan Fu, Lili Niu, Chengdong Wang, Shuxian Wang, Qiang Wang   +15 more
openaire   +5 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source