Results 81 to 90 of about 1,628,733 (342)

Experiences from dual genome next-generation sequencing panel testing for mitochondrial disorders: a comprehensive molecular diagnosis

Frontiers in Genetics
IntroductionThe molecular diagnosis of mitochondrial disorders is complicated by phenotypic variability, genetic heterogeneity, and the complexity of mitochondrial heteroplasmy.
Elizabeth Gorman, Hongzheng Dai, Hongzheng Dai, Yanming Feng, William James Craigen, William James Craigen, David C. Y. Chen, Fan Xia, Fan Xia, Linyan Meng, Linyan Meng, Pengfei Liu, Pengfei Liu, Robert Rigobello, Arpita Neogi, Christine M. Eng, Christine M. Eng, Yue Wang, Yue Wang   +18 more
doaj   +1 more source

Homeostatic responses regulate selfish mitochondrial genome dynamics in C. elegans

bioRxiv, 2016
Selfish genetic elements have profound biological and evolutionary consequences. Mutant mitochondrial genomes (mtDNA) can be viewed as selfish genetic elements that persist in a state of heteroplasmy despite having potentially deleterious consequences to
B. L. Gitschlag, Cait S. Kirby, D. Samuels, R. Gangula, S. Mallal, Maulik R. Patel   +5 more
semanticscholar   +1 more source

Highlight: The Mystery of Mitochondrial Genomes [PDF]

Genome Biology and Evolution, 2013
Alan Christensen was drawn to an intellectual puzzle—a paradox in need of an explanation. Higher plants have bizarre mitochondrial genomes. Like nuclear genomes, these have coding and noncoding sections. When researchers compare one flowering plant with another, the coding regions are remarkably similar.
openaire   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology

Scientific Reports, 2017
Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused DNMT1-isoform1, reported earlier to localize in mitochondria, surprisingly showed its exclusive ...
S. Saini, K. Mangalhara, G. Prakasam, R. Bamezai   +3 more
semanticscholar   +1 more source

The mitochondrial genome of Fusarium oxysporum

Plasmid, 1989
Physical and genetic maps have been constructed for mtDNA from strains of the fungus Fusarium oxysporum representing three pathogenically specialized forms. All three mtDNA maps are circular. Their sizes are 45 kb for F. oxysporum f.sp. raphani and 52 kb for both F. oxysporum f.sp. conglutinans and F. oxysporum f.sp. matthioli.
Plant Pathology Department, University of Florida, Gainesville, Florida 32611 USA ( host institution ), Kistler, H.Corby, Benny, Ulla   +2 more
openaire   +4 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The mitochondrial genome of soybean reveals complex genome structures and gene evolution at intercellular and phylogenetic levels. [PDF]

PLoS ONE, 2013
Determining mitochondrial genomes is important for elucidating vital activities of seed plants. Mitochondrial genomes are specific to each plant species because of their variable size, complex structures and patterns of gene losses and gains during ...
Shengxin Chang, Yankun Wang, Jiangjie Lu, Junyi Gai, Jijie Li, Pu Chu, Rongzhan Guan, Tuanjie Zhao   +7 more
doaj   +1 more source

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial UPR

Nature, 2016
Mitochondrial genomes (mitochondrial DNA, mtDNA) encode essential oxidative phosphorylation (OXPHOS) components. Because hundreds of mtDNAs exist per cell, a deletion in a single mtDNA has little impact.
Yi-Fan Lin, A. Schulz, M. Pellegrino, Yun Lu, S. Shaham, Cole M. Haynes   +5 more
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source