Results 51 to 60 of about 4,850,535 (301)

The yeast vacuolar membrane proteome [PDF]

, 2009
Transport of solutes between the cytosol and the vacuolar lumen is of crucial importance for various functions of vacuoles, including ion homeostasis; detoxification; storage of different molecules such as amino acids, phosphate, and calcium ions; and ...
Poolman, Bert,, Slotboom, Dirk J.,, Breitling, Rainer, Permentier, Hjalmar P.,, Gandhi, Tejas, Breitling, R., Breitling, Rainer,, Slotboom, D.J., Gandhi, Tejas,, Permentier, Hjalmar P., Permentier, H.P., Gandhi, T., Wiederhold, Elena,, Poolman, Bert, Wiederhold, Elena, Wiederhold, E., Poolman, B., Permentier, Hjalmar P.; id_orcid, Slotboom, Dirk J.   +18 more
core   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2.

PLoS ONE, 2015
Leukemic stem cells (LSCs) reside within bone marrow niches that maintain their relatively quiescent state and convey resistance to conventional treatment. Many of the microenvironmental signals converge on RAC GTPases.
Marta E Capala, Henny Maat, Francesco Bonardi, Vincent van den Boom, Jeroen Kuipers, Edo Vellenga, Ben N G Giepmans, Jan Jacob Schuringa   +7 more
doaj   +1 more source

The Uncoupling Protein UCP1 Does Not Increase the Proton Conductance of the Inner Mitochondrial Membrane by Functioning as a Fatty Acid Anion Transporter [PDF]

Journal of Biological Chemistry, 1998
The activity of the brown fat uncoupling protein (UCP1) is regulated by purine nucleotides and fatty acids. Although the inhibition by nucleotides is well established, the activation by fatty acids is still controversial. It has been reported that the ADP/ATP carrier, and possibly other members of the mitochondrial carrier family, mediate fatty acid ...
González-Barroso, M. Mar, Fleury, Christophe, Bouillaud, Frédéric, Nicholls, David G., Rial, Eduardo   +4 more
openaire   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Membrane proteins in the outer mebrane of plastids and mitochondria [PDF]

, 2006
Channels of the plastid and mitochondrial outer membranes facilitate the turnover of molecules and ions via these membranes. Although channels have been studied many questions pertaining to the whole diversity of plastid and mitochondrial channels in ...
Ilkavets, Iryna
core   +1 more source

Protein insertion into the inner membrane of mitochondria: routes and mechanisms

FEBS Open Bio
The inner membrane of mitochondria contains hundreds of different integral membrane proteins. These proteins transport molecules into and out of the matrix, they carry out multifold catalytic reactions and they promote the biogenesis or degradation of ...
Büsra Kizmaz, Annika Nutz, Annika Egeler, Johannes M. Herrmann   +3 more
doaj   +1 more source

The Mitochondrial Tim23 Protein Transport Complex Undergoes Conformational Dynamics Coupled to the Energized State of the Inner Membrane [PDF]

Biophysical Journal, 2014
The TIM23 Complex of the mitochondrial inner membrane (IM) is a multi-component assembly that mediates the translocation of matrix-targeted precursor proteins as well as the integration of membrane proteins. This complex is energetically coupled to both an ATPase motor and the electrochemical proton potential across the IM.
Malhotra, Ketan, Sathappa, Murugappan, Landin, Judith S., Johnson, Arthur E., Alder, Nathan N.   +4 more
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Biosynthetic pathway of mitochondrial ATPase subunit 9 in Neurospora crassa [PDF]

, 1983
Subunit 9 of mitochondrial ATPase (Su9) is synthesized in reticulocyte lysates programmed with Neurospora poly A-RNA, and in a Neurospora cell free system as a precursor with a higher apparent molecular weight than the mature protein (Mr 16,400 vs.
Zimmermann, Richard, Neupert, Walter, Hennig, Bernd, Schmidt, Bernd   +3 more
core   +2 more sources