Results 41 to 50 of about 4,850,535 (301)

The mitochondrial receptor complex [PDF]

, 1993
The receptor complex in the mitochondrial outer membrane, which consists of at least seven different proteins, is responsible for the recognition and translocation of cytosolically synthesized preproteins.
Klei, Ida J. van der; id_orcid, Pfanner, Nikolaus, Schneider, Helmut,, Kiebler, Michael,, Keil, Petra,, Kiebler, Michael, Neupert, Walter, Klei, Ida J. van der,, Klei, Ida J. van der, Pfanner, Nikolaus,, Keil, Petra, Schneider, Helmut, Neupert, Walter,   +12 more
core   +2 more sources

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
W Neupert, Lill, Roland, Harkness, Troy A.A.,, van der Klei, Ida, Neupert, Walter, Harkness, Troy A. A., Klei, Ida J. van der, TA Harkness, Klei, Ida van der,, Nargang, Frank E.,, I van der Klei, Neupert, Walter,, Lill, Roland,, van der Klei, Ida ; id_orcid, Nargang, Frank E., FE Nargang, R Lill   +16 more
core   +3 more sources

Early steps in steroidogenesis: intracellular cholesterol trafficking

Journal of Lipid Research, 2011
Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from cholesterol esters by lysosomal acid lipase (LAL; disordered in Wolman ...
Walter L. Miller, Himangshu S. Bose
doaj   +1 more source

The Effects of Regulatory Lipids on Intracellular Membrane Fusion Mediated by Dynamin-Like GTPases

Frontiers in Cell and Developmental Biology, 2020
Membrane fusion mediates a number of fundamental biological processes such as intracellular membrane trafficking, fertilization, and viral infection. Biological membranes are composed of lipids and proteins; while lipids generally play a structural role,
Yeojin Moon, Youngsoo Jun
doaj   +1 more source

Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential for Endoplasmic Reticulum to Outer Mitochondrial Membrane Protein Transport [PDF]

Scientific Reports, 2017
AbstractMost nuclear-encoded mitochondrial proteins traffic from the cytosol to mitochondria. Some of these proteins localize at mitochondria-associated membranes (MAM), where mitochondria are closely apposed with the endoplasmic reticulum (ER). We have previously shown that the human cytomegalovirus signal-anchored protein known as viral mitochondria ...
Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H. Patterson, Jyoti K. Jaiswal, Anamaris M. Colberg-Poley   +9 more
openaire   +3 more sources

Anomalous diffusion induced by cristae geometry in the inner mitochondrial membrane [PDF]

, 2009
Diffusion of inner membrane proteins is a prerequisite for correct functionality of mitochondria. The complicated structure of tubular, vesicular or flat cristae and their small connections to the inner boundary membrane impose constraints on the ...
Jürgen Bereiter-Hahn, Sukhorukov Valerii M., Sukhorukov, Valerii M., Valerii M Sukhorukov, Bereiter-Hahn Jürgen, Bereiter-Hahn, Jürgen, Valerii M. Sukhorukov   +6 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT

Neurobiology of Disease, 2014
Deficits in axonal transport are thought to contribute to the pathology of many neurodegenerative diseases. Expressing the slow Wallerian degeneration protein (WldS) or related nicotinamide mononucleotide adenyltransferases (NmNATs) protects axons ...
Cheng Fang, Helena Decker, Gary Banker
doaj   +1 more source

Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges

Frontiers in Endocrinology, 2020
Mitochondria are highly dynamic organelles and important for a variety of cellular functions. They constantly undergo fission and fusion events, referred to as mitochondrial dynamics, which affects the shape, size, and number of mitochondria in the cell,
Rong Yu, Urban Lendahl, Monica Nistér, Jian Zhao   +3 more
doaj   +1 more source

Palmitic Acid, but Not Lauric Acid, Induces Metabolic Inflammation, Mitochondrial Fragmentation, and a Drop in Mitochondrial Membrane Potential in Human Primary Myotubes

Frontiers in Nutrition, 2021
The chain length of saturated fatty acids may dictate their impact on inflammation and mitochondrial dysfunction, two pivotal players in the pathogenesis of insulin resistance.
Domenico Sergi, Domenico Sergi, Natalie Luscombe-Marsh, Nenad Naumovski, Nenad Naumovski, Mahinda Abeywardena, Nathan O'Callaghan   +6 more
doaj   +1 more source