Results 181 to 190 of about 42,806 (266)

GDF15 Neutralization Ameliorates Muscle Atrophy and Exercise Intolerance in a Mouse Model of Mitochondrial Myopathy. [PDF]

J Cachexia Sarcopenia Muscle
Flaherty SE, Song L, Albuquerque B, Rinaldi A, Piper M, Shanthappa DH, Chen X, Stansfield J, Asano S, Pashos E, Ross TT, Jagarlapudi S, Sheikh A, Zhang B, Wu Z.   +14 more
europepmc   +1 more source

From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial carrier proteins are essential for cellular physiology as they are active in a wide range of metabolic pathways including production of cellular energy, amino acid synthesis, redox balance and ion homeostasis. The double membrane of mitochondria provides a tightly gated environment through which carrier proteins facilitate the ...
Catherine S. Palmer, Phoebe J. Leeming, Diana Stojanovski   +2 more
wiley   +1 more source

The Effects of SGLT2 Inhibitors on Muscle Health in Older Adults: A Systematic Review and Meta‐Analysis

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
SGLT2 inhibitors reduce skeletal muscle mass modestly in older adults with type 2 diabetes. Forest plot (a) and count our funnel plot (b) show a small but significant pooled reduction in muscle mass (SMD = −0.36, 95% CI [−0.56, −0.15]; I2 = 24.1%), with weight loss occurring predominantly through fat mass reduction.
Weena Joongpan, Nittaya Boonmuen, Pimthong Sinchai, Sarawut Lapmanee, Natawat Klamsakul, Nutthapoom Pathomthongtaweechai   +5 more
wiley   +1 more source

Double‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration

Aging Cell, Volume 25, Issue 4, April 2026.
A novel drug combination (NMN + API) promotes musculoskeletal regeneration in aging. By boosting NAD+, it activates SIRT3 to suppress cellular senescence and enhance differentiation into chondrocytes, osteoblasts, and myocytes. Oral administration reshapes the gut microbiota, increasing production of the anti‐aging metabolite PHS.
Jianfeng Yu, Mingzhuang Hou, Yaoge Deng, Chenqi Yu, Yang Liu, Kang Kang, Xiaowei Xia, Xiaoping Li, Huilin Yang, Dinghua Jiang, Wu Xu, Yijian Zhang, Xuesong Zhu   +12 more
wiley   +1 more source

Cyclosporine A Delays the Terminal Disease Stage in the Tfam KO Mitochondrial Myopathy Mouse Model Without Improving Mitochondrial Energy Production. [PDF]

Muscle Nerve
Chatel B, Varlet I, Ogier AC, Pecchi E, Bernard M, Gondin J, Westerblad H, Bendahan D, Gineste C.   +8 more
europepmc   +1 more source

Exercise Testing, Physical Training and Fatigue in Patients with Mitochondrial Myopathy Related to mtDNA Mutations. [PDF]

J Clin Med, 2021
Jeppesen TD, Madsen KL, Poulsen NS, Løkken N, Vissing J.   +4 more
europepmc   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Sucla2 Knock-Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type-Specific Phenotypes. [PDF]

J Cachexia Sarcopenia Muscle
Lancaster MS, Hafen P, Law AS, Matias C, Meyer T, Fischer K, Miller M, Hao C, Gillespie P, McKinzie D, Brault JJ, Graham BH.   +11 more
europepmc   +1 more source

Remimazolam anesthesia for transcatheter mitral valve repair in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome: a case report. [PDF]

JA Clin Rep, 2022
Kitaura A, Kosumi R, Iwamoto T, Nakao S.
europepmc   +1 more source

Emerging Design Principles at the Forefront of Mitochondrial Transplantation Using Engineering Methodologies: Current Achievements and Future Directions

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
Mitochondrial transplantation is emerging as a method to restore diverse mitochondrial functions, but it faces delivery challenges. Engineering advances address these gaps via tissue targeting, protection from external stresses, and enhanced cellular internalization.
Naoto Yoshinaga, Keiji Numata
wiley   +1 more source