Results 91 to 100 of about 2,001,140 (304)

RETRACTED: Schisandrin B Induces Apoptosis and Cell Cycle Arrest of Gallbladder Cancer Cells

Molecules, 2014
Gallbladder cancer, with high aggressivity and extremely poor prognosis, is the most common malignancy of the bile duct. The main objective of the paper was to investigate the effects of schisandrin B (Sch B) on gallbladder cancer cells and identify the ...
Shan-Shan Xiang, Xu-An Wang, Huai-Feng Li, Yi-Jun Shu, Run-Fa Bao, Fei Zhang, Yang Cao, Yuan-Yuan Ye, Hao Weng, Wen-Guang Wu, Jia-Sheng Mu, Xiang-Song Wu, Mao-Lan Li, Yun-Ping Hu, Lin Jiang, Zhu-Jun Tan, Wei Lu, Feng Liu, Ying-Bin Liu   +18 more
doaj   +1 more source

Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease

npj Parkinson's Disease, 2023
Exercise has been proposed as an effective non-pharmacological management for Parkinson’s disease (PD) patients. Irisin, a recently identified myokine, is increased by exercise and plays pivotal roles in energy metabolism.
Xi Zhang, Sutong Xu, Yong Hu, Qiulu Liu, Chenming Liu, Huazhen Chai, Yuping Luo, Lingjing Jin, Siguang Li   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A study of mitochondrial biogenesis in the rodent nervous system [PDF]

, 2015
This thesis investigates the process of mitochondrial biogenesis in the rodent CNS in the context of neuroinflammatory and neurodegenerative disease. There is mounting evidence of mitochondrial damage in neuroinflammation but very little is known about ...
Desai, R
core  

Role of Cardiolipin in Mitochondrial Signaling Pathways [PDF]

Frontiers in Cell and Developmental Biology, 2017
The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes and plays a role in many mitochondrial processes, including respiration and energy conversion. Pathological changes in CL amount or species composition can have deleterious consequences for mitochondrial function and trigger the production of reactive oxygen ...
openaire   +5 more sources

Ketogenic Diet Alleviates Hippocampal Neurodegeneration Possibly via ASIC1a and the Mitochondria-Mediated Apoptotic Pathway in a Rat Model of Temporal Lobe Epilepsy

Neuropsychiatric Disease and Treatment, 2022
Qi Qiao,1 Zhenzhen Qu,1 Shuang Tian,2 Huifang Cao,3 Yange Zhang,4 Can Sun,5 Lijing Jia,1,* Weiping Wang1,* 1The Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2The Department of
Qiao Q, Qu Z, Tian S, Cao H, Zhang Y, Sun C, Jia L, Wang W   +7 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A mitochondrial import receptor for the ADP/ATP carrier [PDF]

, 1990
We have identified a mitochondrial outer membrane protein of 72 kd (MOM72) that exhibits the properties of an import receptor for the ADP/ATP carrier (AAC), the most abundant mitochondrial protein.
Söllner, Thomas, Pfanner, Nikolaus, Pfaller, Rupert, Neupert, Walter, Griffiths, Gareth   +4 more
core   +1 more source

Evaluation of Neonatal Cardiotoxicity Following Maternal Green Tea Extract Consumption During Pregnancy: An Experimental Rat Study on the Cytochrome c/Caspase-9/Caspase-3 Pathway

Medicina
Background and Objectives: Green tea is known for its powerful antioxidant properties. However, the effects of green tea consumption during pregnancy on neonatal development and the mechanisms of these effects are not fully understood.
Oya Sayın, Selda İldan Çalım, Ayşe Çigel, Seren Gülşen Gürgen   +3 more
doaj   +1 more source