Results 71 to 80 of about 2,001,140 (304)
Deceleration of fusion–fission cycles improves mitochondrial quality control during aging [PDF]
, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Michael Meyer-Hermann +18 more
core +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Mitochondrial angiotensin receptors and cardioprotective pathways [PDF]
American Journal of Physiology-Heart and Circulatory Physiology, 2019 A growing body of data provides strong evidence that intracellular angiotensin II (ANG II) plays an important role in mammalian cell function and is involved in the pathogenesis of human diseases such as hypertension, diabetes, inflammation, fibrosis, arrhythmias, and kidney disease, among others.
Nelson, Escobales +2 more
openaire +2 more sources
ToxicsHexabromocyclododecane (HBCD) is widely used in polystyrene foams, building materials, and electrical equipment as a brominated flame retardant (BFR) and persists in the environment and human body matrix.
Keyan Wan +4 more
doaj +1 more source
Cytotoxic Indole Alkaloids against Human Leukemia Cell Lines from the Toxic Plant Peganum harmala
Toxins, 2015 Bioactivity-guided fractionation was used to determine the cytotoxic alkaloids from the toxic plant Peganum harmala. Two novel indole alkaloids, together with ten known ones, were isolated and identified.
Chunhua Wang +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Digits develop in the distal part of the embryonic limb primordium as radial prechondrogenic condensations separated by undifferentiated mesoderm.
Juan A. Montero +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Mitochondrial pathways to autism
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010 Autism is a severe pervasive developmental disorder characterized by variable degrees of impairment in language, communication and social skills, as well as by repetitive and stereotypic patterns of behaviour. Despite strong familial components, clinical and genetic complexities have posed a major challenge to our understanding of autism pathogenesis ...
Palmieri, Luigi +5 more
openaire +2 more sources
Mitochondrial pathways in human health and aging
Mitochondrion, 2020 Mitochondria are eukaryotic organelles known best for their roles in energy production and metabolism. While often thought of as simply the 'powerhouse of the cell,' these organelles participate in a variety of critical cellular processes including reactive oxygen species (ROS) production, regulation of programmed cell death, modulation of inter- and ...
Rebecca Bornstein +2 more
openaire +3 more sources
An unconventional pathway for mitochondrial protein degradation [PDF]
Autophagy, 2016 Many vital metabolic pathways take place in mitochondria, but some of the associated processes generate toxic substances including reactive oxygen species that can damage proteins and DNA. Therefore, it is critical to maintain normally functioning mitochondria to achieve proper cellular homeostasis.
Zhiyuan, Yao, Daniel J, Klionsky
openaire +2 more sources