Results 51 to 60 of about 2,001,140 (304)

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
W Neupert, Lill, Roland, Harkness, Troy A.A.,, van der Klei, Ida, Neupert, Walter, Harkness, Troy A. A., Klei, Ida J. van der, TA Harkness, Klei, Ida van der,, Nargang, Frank E.,, I van der Klei, Neupert, Walter,, Lill, Roland,, van der Klei, Ida ; id_orcid, Nargang, Frank E., FE Nargang, R Lill   +16 more
core   +3 more sources

A Novel Betulinic Acid Analogue: Synthesis, Solubility, Antitumor Activity and Pharmacokinetic Study in Rats

Molecules, 2023
Betulinic acid (BA) and betulin (BE) are naturally pentacyclic triterpenes with documented biological activities, especially antitumor and anti-inflammatory activity.
Yucen Liang, Meixuan Zhu, Tao Xu, Weimin Ding, Min Chen, Yang Wang, Jian Zheng   +6 more
doaj   +1 more source

Metabolic consequences of neuronal mitochondrial fission ablation [PDF]

, 2016
Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A novel regulator of the p53-mediated mitochondrial apoptotic pathway [PDF]

, 2008
The p53 tumor suppressor protein induces apoptosis in response to genotoxic and environmental stress. Recent studies have revealed the existence of a transcription-independent mitochondrial p53 apoptosis pathway, however the mechanism regulating p53 ...
Bo Young Ahn, Sung-Woo Kim, Diane Trinh, Laura Zajchowski   +3 more
core  

Protein translocation across mitochondrial membranes [PDF]

, 1992
Protein translocation across biological membranes is of fundamental importance for the biogenesis of organelles and in protein secretion. We will give an overview of the recent achievements in the understanding of protein translocation across ...
Walter Neupert, Ulla Wienhues, Neupert, Walter, Wienhues, Ulla   +3 more
core   +1 more source

Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells

Frontiers in Cardiovascular Medicine, 2022
Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels.
Qiu-Ping Liu, Yu-Ying Chen, Yuan-Yuan Yu, Pei An, Yi-Zhuo Xing, Hong-Xuan Yang, Yin-Jian Zhang, Khalid Rahman, Lei Zhang, Xin Luan, Hong Zhang   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Combining Sodium Butyrate With Cisplatin Increases the Apoptosis of Gastric Cancer In Vivo and In Vitro via the Mitochondrial Apoptosis Pathway

Frontiers in Pharmacology, 2021
Introduction: The gastrointestinal malignancy, gastric cancer (GC), has a high incidence worldwide. Cisplatin is a traditional chemotherapeutic drug that is generally applied to treat cancer; however, drug tolerance affects its efficacy.
Yangbo Li, Yangbo Li, Yangbo Li, Pengzhan He, Pengzhan He, Pengzhan He, Yinghui Liu, Yinghui Liu, Yinghui Liu, Mingming Qi, Mingming Qi, Mingming Qi, Weiguo Dong, Weiguo Dong, Weiguo Dong   +14 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source