Results 31 to 40 of about 2,001,140 (304)

The emerging role of Nrf2 in mitochondrial function [PDF]

, 2015
The transcription factor NF-E2 p45-related factor 2 (Nrf2, gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti ...
Dinkova-Kostova, AT, Abramov, Andrey Y., Dinkova-Kostova, Albena T.; id_orcid, Abramov, AY, Dinkova-Kostova, Albena T.   +4 more
core   +1 more source

Neurodegenerative stress related mitochondrial proteostasis [PDF]

, 2015
1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
core   +1 more source

The role of VDAC2 in Bak-, Bax-mediated apoptosis: prospects for use in therapy (a review of literature)

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022
Apoptosis is of great importance for tissue homeostasis and normal embryo- and ontogenesis. Currently great attention is paid to the study of mitochondrial apoptosis that can be realized through the interaction of proteins Bax and Bak, the key ...
A.A. Bolotskaya, V.N. Nikolenko, M.V. San'kova, N.A. Rizaeva   +3 more
doaj   +1 more source

Molecular Mechanisms of Selenium Mitigating Lead Toxicity in Chickens via Mitochondrial Pathway: Selenoproteins, Oxidative Stress, HSPs, and Apoptosis

Toxics, 2023
Lead (Pb), a hazardous heavy metal, can damage the health of organisms. However, it is not clear whether Pb can damage chicken cerebellums and thalami.
Weichen Hong, Yuhao Liu, Jiatian Liang, Chunyu Jiang, Meijin Yu, Wei Sun, Bin Huang, Na Dong, Lu Kang, You Tang   +9 more
doaj   +1 more source

A morphological view on mitochondrial protein targeting [PDF]

, 1994
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ida J. van der Klei, Walter Neupert, Neupert, Walter, Marten Veenhuis, Veenhuis, Marten, Klei, Ida J. van der   +5 more
core   +1 more source

Mitochondrial Quality Control Pathways Sense Mitochondrial Protein Import

Trends in Endocrinology & Metabolism, 2023
Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins, and the
Laurie P. Lee-Glover, Timothy E. Shutt
openaire   +2 more sources

Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity [PDF]

, 2013
There are hints of an altered mitochondrial function in obesity. Nuclear-encoded genes are relevant for mitochondrial function (3 gene sets of known relevant pathways: (1) 16 nuclear regulators of mitochondrial genes, (2) 91 genes for oxidative ...
Wichmann, Heinz-Erich, Martin Klingenspor, Knoll, Nadja, André Scherag, Jarick Ivonne, Hebebrand, J., Anna-Lena Volckmar, Gieger, C., Christian Gieger, Anna-Lena Volckmar (280948), Nadja Knoll (280947), Knoll, N., Christian Gieger (87555), Ivonne Jarick, Hebebrand, Johannes, Klingenspor Martin, Gieger Christian, Grallert, Harald, Wichmann, H.-E., Illig, T., Jarick, Ivonne, Volckmar, Anna-Lena, Wichmann Heinz-Erich, Peters, Annette, Illig Thomas, Ivonne Jarick (250179), Anke Hinney (87545), Johannes Hebebrand, Volckmar Anna-Lena, Peters Annette, Nadja Knoll, Annette Peters (62601), Heinz-Erich Wichmann, Scherag André, Annette Peters, Harald Grallert (72666), Thomas Illig (44906), Klingenspor, Martin, Peters, A., Illig, Thomas, Grallert Harald, Thomas Illig, Harald Grallert, Hebebrand Johannes, Johannes Hebebrand (170268), Gieger, Christian, Anke Hinney, Hinney Anke, Martin Klingenspor (68144), Scherag, André, Klingenspor, M., Grallert, H., Hinney, A., Hinney, Anke, Jarick, I., Volckmar, A.-L., André Scherag (170155), Heinz-Erich Wichmann (280949), Scherag, A., Knoll Nadja, Knoll, N., Jarick, I., Volckmar, A.-L., Klingenspor, M., Illig, T., Grallert, H., Gieger, C., Wichmann, H.-E., Peters, A., Hebebrand, J., Scherag, A., Hinney, A.   +60 more
core   +2 more sources

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells

Molecules, 2020
Benzoxazole derivative K313 has previously been reported to possess anti-inflammatory effects in lipopolysaccharide-induced RAW264.7 macrophages. To date, there have been no related reports on the anticancer effects of K313.
Wenying Zhong, Xinwen Tang, Yang Liu, Chunyu Zhou, Pan Liu, Enhui Li, Peilin Zhong, Haoxue Lv, Qiang Zou, Maolin Wang   +9 more
doaj   +1 more source

Aspernolide A Inhibits the Proliferation of Human Laryngeal Carcinoma Cells through the Mitochondrial Apoptotic and STAT3 Signaling Pathways

Molecules, 2019
Aspernolide A, a butyrolactone secondary metabolite, was purified from the endophytic fungus Cladosporium cladosporioides derived from roots of Camptotheca acuminata Decne.
Chang Liu, Hong Liu, Yanzhang Wen, Huiqi Huang, Ji Hao, Yibing Lv, Rui Qin, Xinzhou Yang   +7 more
doaj   +1 more source

Structure Elucidation and Anti-Tumor Activities of Trichothecenes from Endophytic Fungus Fusariumsporotrichioides

Biomolecules, 2022
The secondary metabolites of Fusarium sporotrichioides, an endophytic fungus with anti-tumor activity isolated from Rauvolfia yunnanensis Tsiang, were investigated.
Ya-Jing Wang, Nan Ma, Yong-Fu Lu, Si-Yang Dai, Xue Song, Chang Li, Yi Sun, Yue-Hu Pei   +7 more
doaj   +1 more source