Results 41 to 50 of about 2,001,140 (304)

Depicting the DNA Binding and Cytotoxicity Studies against Human Colorectal Cancer of Aquabis (1-Formyl-2-Naphtholato-k²O,O′) Copper(II): A Biophysical and Molecular Docking Perspective

Crystals, 2021
In this study, we attempted to examine the biological activity of the copper(II)–based small molecule aquabis (1-formyl-2-naphtholato-k2O,O′)copper(II) (1) against colon cancer. The characterization of complex 1 was established by analytical and spectral
Ebtisam Alolayqi, Mohd Afzal, Abdullah Alarifi, Abeer Beagan, Mohd Muddassir   +4 more
doaj   +1 more source

The Mitochondrial Pathway of Apoptosis: Part I: MOMP and Beyond. [PDF]

Cold Spring Harb Perspect Biol, 2022
Green DR.
europepmc   +3 more sources

Alternative oxidase dependent respiration leads to an increased mitochondrial content in two long-lived mutants of the aging model Podospora anserina [PDF]

, 2011
The retrograde response constitutes an important signalling pathway from mitochondria to the nucleus which induces several genes to allow compensation of mitochondrial impairments.
Koen Houthoofd, Jacques R. Vanfleteren, Werner, Alexandra, Christian Q. Scheckhuber, De Vreese, Annemie, Scheckhuber Christian Q., Andrea C. Weil, Heinz D. Osiewacz, Jacques R Vanfleteren, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Christian Q Scheckhuber, De Vreese Annemie, Houthoofd Koen, Vanfleteren Jacques R., Vanfleteren, Jacques R., Weil Andrea C., Andrea C Weil, Werner Alexandra, Heinz D Osiewacz, Houthoofd, Koen, Osiewacz Heinz D., Alexandra Werner, Annemie De Vreese, Weil, Andrea C.   +24 more
core   +1 more source

Effects of Nicotinamide on Cervical Cancer-Derived Fibroblasts: Evidence for Therapeutic Potential

Cancer Management and Research, 2020
Reem N Hassan,* Hualei Luo,* Weiying Jiang Department of Medical Genetics, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Hassan RN, Luo H, Jiang W
doaj  

DCLAK11 treatment induces apoptosis in non‐small cell lung cancer cells by inhibiting the mitochondrial apoptosis pathway

Precision Radiation Oncology, 2019
Objective DCLAK11 is a novel small molecule tyrosine kinase inhibitor with remarkable effects on cell proliferation and apoptosis in non‐small cell lung cancer cells.
Xiaobin Guo, Hongchun Liu, Jian Ding
doaj   +1 more source

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
Kepp, Oliver, Meinecke, M., Harsman, Anke, Meinecke, Michael, Joachim Rassow, Hauf, Eva, Kepp, O., Günther, Dirk, Oliver Kepp, Richard Wagner, Dirk Günther, Thomas Rudel, Hauf, E., Wagner, R., Katharina Ross, Rassow, Joachim, Volker Brinkmann, Brinkmann, Volker, Rajalingam, Krishnaraj, Ines Herrmann, Elke A. Dian-Lothrop, Brinkmann, V., Kozjak-Pavlovic, V., Günther, D., Kozjak-Pavlovic, Vera, Ross, Katharina, Eva Hauf, Vera Kozjak-Pavlovic, Michael Meinecke, Robert Hurwitz, Dian-Lothrop, E., Wagner, Richard, Ross, K., Rajalingam, K., Rudel, T., Dian-Lothrop, Elke A., Rudel, Thomas, Hurwitz, Robert, Krishnaraj Rajalingam, Harsman, A., Elke A Dian-Lothrop, Herrmann, I., Hurwitz, R., Herrmann, Ines, Rassow, J., Anke Harsman   +45 more
core   +2 more sources

Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity

, 2022
Mitochondrial dysfunction induces a strong adaptive retrograde signaling response; however, many of the downstream effectors of this response remain to be discovered.
Descombes, Patrick, Wiederkehr, Andreas, Lefebvre, Gregory, Santo-Domingo, Jaime, Metairon, Sylviane, Wall, Christopher Tadhg James   +5 more
core   +1 more source

Nuclear and mitochondrial apoptotic pathways of p53 [PDF]

FEBS Letters, 2001
In contrast to p53‐mediated cell cycle arrest, the mechanisms of p53‐mediated apoptosis in response to cellular stresses such as DNA damage, hypoxia and oncogenic signals still remain poorly understood. Elucidating these pathways is all the more pressing since there is good evidence that the activation of apoptosis rather than cell cycle arrest is ...
Moll, Ute M, Zaika, Alex
openaire   +2 more sources

Synthetic Flavanones Augment the Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Molecules, 2012
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered as the most promising anticancer agent in the TNF superfamily because of its selective cytotoxicity against tumor cells versus normal primary cells.
Wojciech Krol, Zenon P. Czuba, Dagmara Jaworska, Tomasz Janeczko, Joanna Bronikowska, Ewelina Szliszka, Edyta Kostrzewa-Susłow   +6 more
doaj   +1 more source

Regulation of Mitochondrial Antiviral Signaling Pathways [PDF]

Immunity, 2008
Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon.
Moore, Chris B., Ting, Jenny P-Y.
openaire   +2 more sources