Results 11 to 20 of about 2,001,140 (304)

Effects of statins on mitochondrial pathways [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2021
AbstractStatins are a family of drugs that are used for treating hyperlipidaemia with a recognized capacity to prevent cardiovascular disease events. They inhibit β‐hydroxy β‐methylglutaryl‐coenzyme A reductase, i.e. the rate‐limiting enzyme in mevalonate pathway, reduce endogenous cholesterol synthesis, and increase low‐density lipoprotein clearance ...
Hamid Mollazadeh, Erfan Tavana, Giovanni Fanni, Simona Bo, Maciej Banach, Matteo Pirro, Stephan von Haehling, Tannaz Jamialahmadi, Amirhossein Sahebkar   +8 more
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Mitochondrial longevity pathways

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Production of reactive oxygen species (ROS) is a tightly regulated process, and increased levels of ROS within mitochondria are the principal trigger not only for mitochondrial dysfunctions but, more in general, for the diseases associated with aging, thus representing a powerful signaling molecules.
RAFFAELLO, ANNA, RIZZUTO, ROSARIO
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Biosynthetic pathway of mitochondrial ATPase subunit 9 in Neurospora crassa [PDF]

, 1983
Subunit 9 of mitochondrial ATPase (Su9) is synthesized in reticulocyte lysates programmed with Neurospora poly A-RNA, and in a Neurospora cell free system as a precursor with a higher apparent molecular weight than the mature protein (Mr 16,400 vs.
Zimmermann, Richard, Neupert, Walter, Hennig, Bernd, Schmidt, Bernd   +3 more
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Morphological Pathways of Mitochondrial Division [PDF]

Antioxidants, 2018
Mitochondrial fission is essential for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation. Excessive fission is associated with the progression of cell death as well.
Bernard Tandler, Charles L. Hoppel, Jason A. Mears   +2 more
openaire   +3 more sources

The Mitochondrial Pathways of Apoptosis [PDF]

, 2011
Apoptosis is a process of programmed cell death that serves as a major mechanism for the precise regulation of cell numbers, and as a defense mechanism to remove unwanted and potentially dangerous cells. Studies in nematode, Drosophila and mammals have shown that, although regulation of the cell death machinery is somehow different from one species to ...
Estaquier, Jérome, Vallette, François, Vayssière, Jean-Luc, Mignotte, Bernard   +3 more
openaire   +4 more sources

The mitochondrial pathway in yeast apoptosis [PDF]

Apoptosis, 2007
Mitochondria are not only important for the energetic status of the cell, but are also the fatal organelles deciding about cellular life and death. Complex mitochondrial features decisive for cell death execution in mammals are present and functional in yeast: AIF and cytochrome c release to the cytosol, mitochondrial fragmentation as well as ...
Tobias, Eisenberg, Sabrina, Büttner, Guido, Kroemer, Frank, Madeo   +3 more
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Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration [PDF]

, 2013
Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes.
Iain Hargreaves, Land, John M., Kira M. Holmström, Andrey Y. Abramov, Chalasani, A, Annapurna Chalasani, Holmstrom, KM, Masayuki Yamamoto, Baird, Liam, Baird, L, John M. Land, Yamamoto, Masayuki, Lee Stanyer, Land, JM, Dinkova-Kostova, AT, Holmström, Kira M., Liam Baird, Albena T. Dinkova-Kostova, Ying Zhang, Abramov, Andrey Y., Zhang, Y, Hargreaves, Iain, Chalasani, Annapurna, Abramov, AY, Stanyer, L, Hargreaves, IP, Yamamoto, M, Zhang, Ying, Stanyer, Lee, Dinkova-Kostova, Albena T.; id_orcid   +29 more
core   +1 more source

Mitoptosis: Different Pathways for Mitochondrial Execution [PDF]

Autophagy, 2007
Mitoptosis was described as a sort of mitochondrial death program. It could be associated with both necrosis and apoptosis, although degenerating mitochondria are also found in autophagic vacuoles. It was demonstrated that several molecules might contribute to the remodeling and rearrangement of mitochondrial membranes, leading to mitochondria rupture ...
A. Tinari, GAROFALO, TINA, SORICE, Maurizio, M. D. Degli Esposti, W. Malorni   +4 more
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A mitochondrial pathway for biosynthesis of lipid mediators [PDF]

Nature Chemistry, 2014
The central role of mitochondria in metabolic pathways and in cell-death mechanisms requires sophisticated signalling systems. Essential in this signalling process is an array of lipid mediators derived from polyunsaturated fatty acids. However, the molecular machinery for the production of oxygenated polyunsaturated fatty acids is localized in the ...
Tyurina, Yulia Y., Poloyac, Samuel M., Tyurin, Vladimir A., Kapralov, Alexander A., Jiang, Jianfei, Anthonymuthu, Tamil Selvan, Kapralova, Valentina I., Vikulina, Anna S., Jung, Mi-Yeon, Epperly, Michael W., Mohammadyani, Dariush, Klein-Seetharaman, Judith, Jackson, Travis C., Kochanek, Patrick M., Pitt, Bruce R., Greenberger, Joel S., Vladimirov, Yury A., Bayır, Hülya, Kagan, Valerian E.   +18 more
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Compound Ammonium Glycyrrhizin Protects Hepatocytes from Injury Induced by Lipopolysaccharide/Florfenicol through a Mitochondrial Pathway

Molecules, 2018
Florfenicol (FFC), a widely used drug for chicken diseases, can aggravate lipopolysaccharide (LPS) damage to the liver. For this condition, natural or synthetic products displaying strong antioxidant capacity are expected to prevent LPS/FFC from inducing
Wenyang Li, Ying Li, Xiangyuan Jiang, Xiaohui Li, Zugong Yu   +4 more
doaj   +1 more source