Results 271 to 280 of about 2,001,140 (304)
Some of the next articles are maybe not open access.
Activation of the mitochondrial pathway of apoptosis by oxysterols
Frontiers in Bioscience, 2007A significant fraction of cholesterol that accumulates in atherosclerotic lesions is actually oxidized to yield a number of derivatives, named oxysterols, which are provided with much stronger biochemical effects than the parental compound. Of note, an increasing bulk of studies is giving evidence of accumulation of oxysterols in a number of other ...
LEONARDUZZI, Gabriella Marisa +3 more
openaire +2 more sources
Mitochondrial dysfunction and molecular pathways of disease
Experimental and Molecular Pathology, 2007Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health, disease, and aging. A wide range of seemingly unrelated disorders, such as schizophrenia, bipolar disease, dementia, Alzheimer's disease, epilepsy, migraine headaches, strokes, neuropathic pain ...
Steve R, Pieczenik, John, Neustadt
openaire +2 more sources
Mitochondrial Longevity Pathways
2016This chapter describes our current knowledge of a fascinating class of C. elegans longevity mutants, the mitochondrial (Mit) mutants, whose lifespan extension is paradoxically triggered by interventions that directly or indirectly affect the functionality of the mitochondrial electron transport chain.
Alfonso Schiavi, Natascia Ventura
openaire +1 more source
Mitochondrial pathway of apoptosis
The FASEB Journal, 2017Our studies of programmed cell death in the last twenty years have taken into three interwoven directions. The first is to identify the molecular components and biochemical reactions of cell death programs; Secondly, to understand the physiological and pathological significance of programmed cell death; and finally, to derive therapeutic strategies ...
openaire +1 more source
Thyroid Hormone Action: The Mitochondrial Pathway
Science, 1977The subcellular compartments have been investigated to compare proteins capable of binding triiodothyronine and thyroxine; specific binders have been found in cytosol, nuclei, and mitochondria from rat liver and kidney. The binding protein from the inner mitochondrial membrane had the highest association constant (> 10 11
K, Sterling +3 more
openaire +2 more sources
Batten Disease and Mitochondrial Pathways of Proteolysis
Biochemical and Molecular Medicine, 1996Most forms of Batten Disease (BD), a group of neurodegenerative diseases, are characterized by the accumulation within lysosomes of the very hydrophobic protein subunit 9 of the mitochondrial F1F0-ATP synthase (F-ATPase). It is now known that the cause of the accumulation of this protein in BD is a reduction in its rate of degradation.
A J, Tanner, J F, Dice
openaire +2 more sources
Mitochondrial dysfunction affecting visual pathways
Revue Neurologique, 2014Mitochondrial dysfunction leads to cellular energetic impairment, which may affect the visual pathways, from the retina to retrochiasmal structures. The most common mitochondrial optic neuropathies include Leber's hereditary optic neuropathy and autosomal dominant optic atrophy, but the optic nerve can be affected in other syndromic conditions, such as
Leruez, Stéphanie +6 more
openaire +2 more sources
The Mitochondrial Apoptosis Pathway
2003Multicellular organisms are dependent on the removal of damaged or unwanted cells both during their development and in the adult life. This is ensured by apoptosis or programmed cell death. Apoptosis is an active energy (ATP) requiring process where cells are eliminated in an ordered manner.
openaire +1 more source
The Mitochondrial Pathway: Focus on Shape Changes
2009Mitochondria are key participants in cell death. They amplify death signals by releasing proapoptotic proteins normally stored in their intermembrane space, such as cytochrome c. In recent years, cytochrome c release has been demonstrated to be not only highly regulated by the proteins of the Bcl-2 family, but also influenced by changes in ...
Campello S., Scorrano L.
openaire +1 more source
Transamination and the Control of Mitochondrial Pathways
Nature, 1961H, GUTFREUND, K E, EBNER, L, MENDIOLA
openaire +2 more sources