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Mitochondrial Proteins as Exosomal Cargo: New Breast Cancer Biomarkers & Crucial Players in Carcinogenesis? [PDF]

Molecules
Mitochondrial proteins (mtPs) packaged into extracellular vesicles (EVs), particularly exosomes, have emerged as promising biomarkers and functional mediators in cancer biology.
Aleksei Shefer, Lyudmila Yanshole, Alina Grygor’eva, Natalia Yunusova, Irina Kondakova, Liudmila Spirina, Andrey Shevela, Alyona Chernyshova, Alexander Romanov, Svetlana Tamkovich   +9 more
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Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis [PDF]

Frontiers in Pharmacology
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonly occurring in type 1 diabetes (T1D) but also seen in type 2 diabetes (T2D).
Ruiqiang Xie, Hongyan Xie, Hong Gao, Chunguang Xie, Haipo Yuan, Zhijun Feng   +5 more
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Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases [PDF]

Brain and Behavior
Background Neurodegenerative diseases involve progressive neuronal dysfunction and cognitive decline, posing substantial global challenges. Although the precise causes remain unclear, several studies highlight the role of protein metabolism abnormalities
Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu   +10 more
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Mitochondrial proteins: Potential pathophysiological mechanisms of malignant progression in HCC. [PDF]

PLoS ONE
ObjectiveBased on the special role of mitochondria in tumour energy metabolism. We hope to explore the pathogenesis and potential therapeutic targets of Hepatocellular carcinoma by analysing the expression of 1136 mitochondrial proteins in hepatocellular
Yicun Liu, Yawen Shao, Xudong Zhu, Zhouming Shen, Zhaolian Bian   +4 more
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Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) [PDF]

Diabetes & Metabolism Journal, 2022
Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism.
Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim   +3 more
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Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins

Biomolecules, 2022
The importance of mitochondria in mammalian cells is widely known. Several biochemical reactions and pathways take place within mitochondria: among them, there are those involving the biogenesis of the iron–sulfur (Fe-S) clusters.
Francesca Camponeschi, Simone Ciofi-Baffoni, Vito Calderone, Lucia Banci   +3 more
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The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes

Reviews in Cardiovascular Medicine, 2022
Background: Humanin and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) are mitochondrial encoded peptides involved in energy metabolism, cytoprotection, longevity, insulin sensitivity and their expression decrease with age.
Maha Alser, Manjunath Ramanjaneya, Najeha Rizwana Anwardeen, Francesco Donati, Francesco Botrè, Jayakumar Jerobin, Ilham Bettahi, Nura Adam Mohamed, Abdul Badi Abou-Samra, Mohamed A Elrayess   +9 more
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Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Biomolecules, 2021
Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced.
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, José Pedraza-Chaverri   +3 more
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The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses

Antioxidants, 2021
Horses have one of the highest skeletal muscle oxidative capacities amongst mammals, which, combined with a high glycolytic capacity, could perturb redox status during maximal exercise.
Marisa L. Henry, Deborah Velez-Irizarry, Joe D. Pagan, Lorraine Sordillo, Jeff Gandy, Stephanie J. Valberg   +5 more
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Mitochondrial protein dysfunction in pathogenesis of neurological diseases

Frontiers in Molecular Neuroscience, 2022
Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal ...
Liang Wang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Xiumei He, Xiumei He, Xiumei He, Shiming Pu, Shiming Pu, Shiming Pu, Cheng Yang, Cheng Yang, Cheng Yang, Qiong Wu, Qiong Wu, Qiong Wu, Zuping Zhou, Zuping Zhou, Xiaobo Cen, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao   +23 more
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