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Biogenesis of mitochondrial proteins [PDF]

Current Opinion in Cell Biology, 1989
Numerous components have been identified that participate at various stages in the biogenesis of mitochondria. For many of these components, their specific functions have recently been defined through detailed investigations of the molecular mechanisms underlying protein targeting, translocation across the mitochondrial outer and inner membranes ...
A Rietveld, A Rietveld, A Rietveld, A Rietveld, A Rietveld, AK Hopper, AL Horwich, B Chatton, B Hennig, B Hennig, B Schmid, C Zwizinski, C Zwizinski, CR Hackenbrock, D Ricquier, DW Nicholson, EC Hurt, EC Hurt, EC Hurt, EC Hurt, F Bouilland, F-U Hartl, F-U Hartl, F-U Hartl, G Hawlitschek, G Heijne von, G Natsoulis, GS Adrian, H Aquila, H Freitag, H Korb, H Riezmann, HJ Gabius, JG Conboy, JP Beltzer, K Mihara, K Mihara, K Verner, K Watanabe, KB Freeman, M Eilers, M Eilers, M Mori, M Nguyen, M Saraste, M Schleyer, M Schleyer, M Schwaiger, M Tropschug, M Wu, ME Dumont, MG Douglas, MP Yaffe, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, P Böhm, PC Böhni, PC McAda, R Kleene, R Pfaller, R Pfaller, R Zimmermann, R Zimmermann, RA Stuart, RG Ridley, S Matsuura, S Miura, S Miura, S Ohta, SD Emr, SM Gasser, SM Gasser, SM Gasser, T Hase, T Hase, T Sollner, W Neupert, W-J Chen, W-J Chen   +84 more
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Import of mitochondrial proteins [PDF]

Biochemical Society Transactions, 1984
Publisher Summary This chapter describes the structural organization and function of the import systems that mediate protein targeting to mitochondria, and how genetic alterations of these systems contribute to the development of neurodegenerative disorders in humans.
Harmey, Matthew A., Neupert, Walter
core   +6 more sources

Mitochondrial Proteins as Exosomal Cargo: New Breast Cancer Biomarkers & Crucial Players in Carcinogenesis? [PDF]

Molecules
Mitochondrial proteins (mtPs) packaged into extracellular vesicles (EVs), particularly exosomes, have emerged as promising biomarkers and functional mediators in cancer biology.
Aleksei Shefer, Lyudmila Yanshole, Alina Grygor’eva, Natalia Yunusova, Irina Kondakova, Liudmila Spirina, Andrey Shevela, Alyona Chernyshova, Alexander Romanov, Svetlana Tamkovich   +9 more
doaj   +2 more sources

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis [PDF]

Frontiers in Pharmacology
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonly occurring in type 1 diabetes (T1D) but also seen in type 2 diabetes (T2D).
Ruiqiang Xie, Hongyan Xie, Hong Gao, Chunguang Xie, Haipo Yuan, Zhijun Feng   +5 more
doaj   +2 more sources

Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases [PDF]

Brain and Behavior
Background Neurodegenerative diseases involve progressive neuronal dysfunction and cognitive decline, posing substantial global challenges. Although the precise causes remain unclear, several studies highlight the role of protein metabolism abnormalities
Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu   +10 more
doaj   +2 more sources

Mitochondrial proteins: Potential pathophysiological mechanisms of malignant progression in HCC. [PDF]

PLoS ONE
ObjectiveBased on the special role of mitochondria in tumour energy metabolism. We hope to explore the pathogenesis and potential therapeutic targets of Hepatocellular carcinoma by analysing the expression of 1136 mitochondrial proteins in hepatocellular
Yicun Liu, Yawen Shao, Xudong Zhu, Zhouming Shen, Zhaolian Bian   +4 more
doaj   +2 more sources

Sorting out mitochondrial proteins [PDF]

Trends in Cell Biology, 1993
Lill, Roland, Neupert, Walter, Stuart, Rosemary A.   +2 more
core   +5 more sources

Mitochondrial protein import [PDF]

, 1994
The transport of nuclear-encoded proteins from the cytosol into mitochondria is mediated by targeting (signal) sequences present on precursor forms.
Neupert, Walter, Schwarz, Elisabeth
core   +3 more sources

Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) [PDF]

Diabetes & Metabolism Journal, 2022
Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism.
Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim   +3 more
doaj   +1 more source

Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins

Biomolecules, 2022
The importance of mitochondria in mammalian cells is widely known. Several biochemical reactions and pathways take place within mitochondria: among them, there are those involving the biogenesis of the iron–sulfur (Fe-S) clusters.
Francesca Camponeschi, Simone Ciofi-Baffoni, Vito Calderone, Lucia Banci   +3 more
doaj   +1 more source