Results 1 to 10 of about 6,525,414 (422)

A nuclear-based quality control pathway for non-imported mitochondrial proteins [PDF]

eLife, 2021
Mitochondrial import deficiency causes cellular toxicity due to the accumulation of non-imported mitochondrial precursor proteins, termed mitoprotein-induced stress.
Viplendra PS Shakya, William A Barbeau, Tianyao Xiao, Christina S Knutson, Max H Schuler, Adam L Hughes   +5 more
doaj   +3 more sources

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. [PDF]

Nat Commun, 2022
Abnormalities in brain glucose metabolism and accumulation of abnormal protein deposits called plaques and tangles are neuropathological hallmarks of Alzheimer’s disease (AD), but their relationship to disease pathogenesis and to each other remains ...
Yang Y, Tapias V, Acosta D, Xu H, Chen H, Bhawal R, Anderson ET, Ivanova E, Lin H, Sagdullaev BT, Chen J, Klein WL, Viola KL, Gandy S, Haroutunian V, Beal MF, Eliezer D, Zhang S, Gibson GE.   +18 more
europepmc   +2 more sources

Biogenesis of mitochondrial proteins [PDF]

Current Opinion in Cell Biology, 1989
Numerous components have been identified that participate at various stages in the biogenesis of mitochondria. For many of these components, their specific functions have recently been defined through detailed investigations of the molecular mechanisms underlying protein targeting, translocation across the mitochondrial outer and inner membranes ...
A Rietveld, A Rietveld, A Rietveld, A Rietveld, A Rietveld, AK Hopper, AL Horwich, B Chatton, B Hennig, B Hennig, B Schmid, C Zwizinski, C Zwizinski, CR Hackenbrock, D Ricquier, DW Nicholson, EC Hurt, EC Hurt, EC Hurt, EC Hurt, F Bouilland, F-U Hartl, F-U Hartl, F-U Hartl, G Hawlitschek, G Heijne von, G Natsoulis, GS Adrian, H Aquila, H Freitag, H Korb, H Riezmann, HJ Gabius, JG Conboy, JP Beltzer, K Mihara, K Mihara, K Verner, K Watanabe, KB Freeman, M Eilers, M Eilers, M Mori, M Nguyen, M Saraste, M Schleyer, M Schleyer, M Schwaiger, M Tropschug, M Wu, ME Dumont, MG Douglas, MP Yaffe, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, P Böhm, PC Böhni, PC McAda, R Kleene, R Pfaller, R Pfaller, R Zimmermann, R Zimmermann, RA Stuart, RG Ridley, S Matsuura, S Miura, S Miura, S Ohta, SD Emr, SM Gasser, SM Gasser, SM Gasser, T Hase, T Hase, T Sollner, W Neupert, W-J Chen, W-J Chen   +84 more
core   +10 more sources

Import of mitochondrial proteins [PDF]

Biochemical Society Transactions, 1984
Publisher Summary This chapter describes the structural organization and function of the import systems that mediate protein targeting to mitochondria, and how genetic alterations of these systems contribute to the development of neurodegenerative disorders in humans.
Harmey, Matthew A., Neupert, Walter
core   +8 more sources

Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]

Electrophoresis 27 (04/2006) 1574-83, 2006
The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial rRNAs and a few tRNAs, we performed a comparative study on the 143B cell line and on its Rho-0 ...
Abdul, Appleby, Armstrong, Bai, Bourges, Buchet, Chai, Claros, Da Cruz, Dey, Du, Garcia, Gianazza, Joseph, King, King, Lescuyer, Luche, Manjasetty, Martinus, Perkins, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Santoni, Sharma, Sharp, Sherer, Singh, Sinha, Suzuki, Tastet, Taylor, Tryoen-Toth, Ugalde, Wiedemann, Zamzami, Zischka   +39 more
arxiv   +6 more sources

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins. [PDF]

Elife, 2021
Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to understand whether failures in the mitochondrial uptake of these nuclear-
Nowicka U, Chroscicki P, Stroobants K, Sladowska M, Turek M, Uszczynska-Ratajczak B, Kundra R, Goral T, Perni M, Dobson CM, Vendruscolo M, Chacinska A.   +11 more
europepmc   +2 more sources

Interactions among mitochondrial proteins altered in glioblastoma [PDF]

Journal of Neuro-Oncology, 2014
Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function.
A Acharya, A Herrmann, AG Herrmann, Alice M. J. Gerth, AM Gallegos, B Venkatesan, BB Ordys, C Miller, CE Griguer, CK Thorpe, DS Ziegler, DW Kang, DY Jin, DY Noh, E Anderson, F Forner, FB Furnari, G Bernard, G Dennis, H Barsnes, H Yan, HJ Lee, Ian R. Whittle, IR Griffiths, James McCulloch, JE Payton, JH Park, JM Cuezva, Julia M. Edgar, KA Sacksteder, L Dang, Lorraine E. Kerr, M Darsigny, MA Nikiforov, Mailis McCulloch, ME Cullen, MS Alphey, N Hempel, PR Rich, R Brigelius-Flohe, R James, R Moreno-Sanchez, RF Deighton, RF Deighton, RJ Shaw, Ruth F. Deighton, RY Lupertz, Sarah F. Martin, SM Cortes, T Bihan Le, T Kanekura, Thierry Le Bihan, TN Seyfried, VL Kinnula, W Huang da, W Tang, Y Fu, Z Yang, Z-Y Li   +58 more
core   +5 more sources

Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases [PDF]

Brain and Behavior
Background Neurodegenerative diseases involve progressive neuronal dysfunction and cognitive decline, posing substantial global challenges. Although the precise causes remain unclear, several studies highlight the role of protein metabolism abnormalities
Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu   +10 more
doaj   +2 more sources

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis [PDF]

Frontiers in Pharmacology
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonly occurring in type 1 diabetes (T1D) but also seen in type 2 diabetes (T2D).
Ruiqiang Xie, Hongyan Xie, Hong Gao, Chunguang Xie, Haipo Yuan, Zhijun Feng   +5 more
doaj   +2 more sources

Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3

Frontiers in Physiology, 2018
A growing number of studies have demonstrated the role of post-translational modifications of proteins, particularly acetylation, in human diseases including neurodegenerative and cardiovascular diseases, diabetes, cancer, and in aging.
Rebecca M. Parodi-Rullán, Xavier R. Chapa-Dubocq, Sabzali Javadov   +2 more
doaj   +2 more sources