Results 11 to 20 of about 802,688 (257)

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis. [PDF]

Front Pharmacol
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonly occurring in type 1 diabetes (T1D) but also seen in type 2 diabetes (T2D).
Xie R, Xie H, Gao H, Xie C, Yuan H, Feng Z.   +5 more
europepmc   +2 more sources

Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases. [PDF]

Brain Behav
Background Neurodegenerative diseases involve progressive neuronal dysfunction and cognitive decline, posing substantial global challenges. Although the precise causes remain unclear, several studies highlight the role of protein metabolism abnormalities
Wang F, Jing Z, Wang Q, Li M, Lu B, Huo A, Zhao C, Zhou H, Liang W, Hu W, Fu X.   +10 more
europepmc   +2 more sources

Import of mitochondrial proteins [PDF]

Biochemical Society Transactions, 1984
Publisher Summary This chapter describes the structural organization and function of the import systems that mediate protein targeting to mitochondria, and how genetic alterations of these systems contribute to the development of neurodegenerative disorders in humans.
Harmey, Matthew A., Neupert, Walter
core   +8 more sources

Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) [PDF]

Diabetes & Metabolism Journal, 2022
Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism.
Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim   +3 more
doaj   +1 more source

Sorting out mitochondrial proteins [PDF]

Trends in Cell Biology, 1993
Lill, Roland, Neupert, Walter, Stuart, Rosemary A.   +2 more
core   +6 more sources

Proteinaceous receptors for the import of mitochondrial precursor proteins [PDF]

, 1984
Mild trypsin treatment of isolated Neurospora mitochondria strongly inhibits their ability to bind and import the precursors of several mitochondrial proteins.
Neupert, Walter, Schleyer, Manfred, Zwizinski, Craig   +2 more
core   +2 more sources

Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins

Biomolecules, 2022
The importance of mitochondria in mammalian cells is widely known. Several biochemical reactions and pathways take place within mitochondria: among them, there are those involving the biogenesis of the iron–sulfur (Fe-S) clusters.
Francesca Camponeschi, Simone Ciofi-Baffoni, Vito Calderone, Lucia Banci   +3 more
doaj   +1 more source

Mitochondrial protein dysfunction in pathogenesis of neurological diseases

Frontiers in Molecular Neuroscience, 2022
Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal ...
Liang Wang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Xiumei He, Xiumei He, Xiumei He, Shiming Pu, Shiming Pu, Shiming Pu, Cheng Yang, Cheng Yang, Cheng Yang, Qiong Wu, Qiong Wu, Qiong Wu, Zuping Zhou, Zuping Zhou, Xiaobo Cen, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao   +23 more
doaj   +1 more source

Mitochondrial protein import [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of
Hartl, Franz-Ulrich, Pfanner, Nikolaus, Nicholson, Donald W., Neupert, Walter   +3 more
openaire   +5 more sources

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis [PDF]

Nucleic Acids Research, 2012
Mitochondrial ribosomes and translation factors co-purify with mitochondrial nucleoids of human cells, based on affinity protein purification of tagged mitochondrial DNA binding proteins. Among the most frequently identified proteins were ATAD3 and prohibitin, which have been identified previously as nucleoid components, using a variety of methods ...
He, J, Cooper, HM, Reyes, A, Di Re, M, Sembongi, H, Litwin, TR, Gao, J, Neuman, KC, Fearnley, IM, Spinazzola, A, Walker, JE, Holt, IJ   +11 more
openaire   +4 more sources