Results 11 to 20 of about 914,673 (333)

Mitochondrial protein import [PDF]

, 1994
The transport of nuclear-encoded proteins from the cytosol into mitochondria is mediated by targeting (signal) sequences present on precursor forms.
Neupert, Walter, Schwarz, Elisabeth
core   +3 more sources

Import of mitochondrial proteins [PDF]

Biochemical Society Transactions, 1984
Publisher Summary This chapter describes the structural organization and function of the import systems that mediate protein targeting to mitochondria, and how genetic alterations of these systems contribute to the development of neurodegenerative disorders in humans.
Harmey, Matthew A., Neupert, Walter
core   +6 more sources

Sorting out mitochondrial proteins [PDF]

Trends in Cell Biology, 1993
Lill, Roland, Neupert, Walter, Stuart, Rosemary A.   +2 more
core   +5 more sources

Biogenesis of mitochondrial proteins [PDF]

Current Opinion in Cell Biology, 1989
Numerous components have been identified that participate at various stages in the biogenesis of mitochondria. For many of these components, their specific functions have recently been defined through detailed investigations of the molecular mechanisms underlying protein targeting, translocation across the mitochondrial outer and inner membranes ...
A Rietveld, A Rietveld, A Rietveld, A Rietveld, A Rietveld, AK Hopper, AL Horwich, B Chatton, B Hennig, B Hennig, B Schmid, C Zwizinski, C Zwizinski, CR Hackenbrock, D Ricquier, DW Nicholson, EC Hurt, EC Hurt, EC Hurt, EC Hurt, F Bouilland, F-U Hartl, F-U Hartl, F-U Hartl, G Hawlitschek, G Heijne von, G Natsoulis, GS Adrian, H Aquila, H Freitag, H Korb, H Riezmann, HJ Gabius, JG Conboy, JP Beltzer, K Mihara, K Mihara, K Verner, K Watanabe, KB Freeman, M Eilers, M Eilers, M Mori, M Nguyen, M Saraste, M Schleyer, M Schleyer, M Schwaiger, M Tropschug, M Wu, ME Dumont, MG Douglas, MP Yaffe, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, N Pfanner, P Böhm, PC Böhni, PC McAda, R Kleene, R Pfaller, R Pfaller, R Zimmermann, R Zimmermann, RA Stuart, RG Ridley, S Matsuura, S Miura, S Miura, S Ohta, SD Emr, SM Gasser, SM Gasser, SM Gasser, T Hase, T Hase, T Sollner, W Neupert, W-J Chen, W-J Chen   +84 more
core   +8 more sources

Mitochondrial protein homeostasis [PDF]

IUBMB Life, 2013
AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova, Diana, Stojanovski, Agnieszka, Chacinska   +2 more
openaire   +2 more sources

Mitochondrial protein import [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of
Hartl, Franz-Ulrich, Pfanner, Nikolaus, Nicholson, Donald W., Neupert, Walter   +3 more
openaire   +4 more sources

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis [PDF]

Nucleic Acids Research, 2012
Mitochondrial ribosomes and translation factors co-purify with mitochondrial nucleoids of human cells, based on affinity protein purification of tagged mitochondrial DNA binding proteins. Among the most frequently identified proteins were ATAD3 and prohibitin, which have been identified previously as nucleoid components, using a variety of methods ...
He, J, Cooper, HM, Reyes, A, Di Re, M, Sembongi, H, Litwin, TR, Gao, J, Neuman, KC, Fearnley, IM, Spinazzola, A, Walker, JE, Holt, IJ   +11 more
openaire   +3 more sources

Mitochondrial Quality Control Pathways Sense Mitochondrial Protein Import

Trends in Endocrinology & Metabolism, 2023
Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins, and the
Laurie P. Lee-Glover, Timothy E. Shutt
openaire   +2 more sources

Restricted mitochondrial protein acetylation initiates mitochondrial autophagy [PDF]

Journal of Cell Science, 2013
As nutrient-sensing nuclear/cytosolic acetylation mediates cellular autophagy, we investigated whether mitochondrial acetylation modulates mitochondrial autophagy. Knockdown of GCN5L1, a component of the mitochondrial acetyltransferase machinery, diminished mitochondrial protein acetylation and augmented mitochondrial enrichment of autophagy mediators.
Bradley R, Webster, Iain, Scott, Kim, Han, Jian H, Li, Zhongping, Lu, Mark V, Stevens, Daniela, Malide, Yong, Chen, Leigh, Samsel, Patricia S, Connelly, Mathew P, Daniels, J Philip, McCoy, Christian A, Combs, Marjan, Gucek, Michael N, Sack   +14 more
openaire   +2 more sources

IRE1 KNOCKDOWN MODIFIES THE GLUTAMINE AND GLUCOSE DEPRIVATION EFFECT ON THE EXPRESSION OF NUCLEAR GENES ENCODING MITOCHONDRIAL PROTEINS IN U87 GLIOMA CELLS [PDF]

Biotechnologia Acta, 2016
We have studied the glucose and glutamine deprivation effect on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
O. O. , D. O. , D. O. , O.O. , O. H.
doaj   +1 more source