Results 11 to 20 of about 902,534 (304)

Mitochondrial protein homeostasis [PDF]

IUBMB Life, 2013
AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova, Diana, Stojanovski, Agnieszka, Chacinska   +2 more
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The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes

Reviews in Cardiovascular Medicine, 2022
Background: Humanin and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) are mitochondrial encoded peptides involved in energy metabolism, cytoprotection, longevity, insulin sensitivity and their expression decrease with age.
Maha Alser, Manjunath Ramanjaneya, Najeha Rizwana Anwardeen, Francesco Donati, Francesco Botrè, Jayakumar Jerobin, Ilham Bettahi, Nura Adam Mohamed, Abdul Badi Abou-Samra, Mohamed A Elrayess   +9 more
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Mitochondrial protein import [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of
Hartl, Franz-Ulrich, Pfanner, Nikolaus, Nicholson, Donald W., Neupert, Walter   +3 more
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Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Biomolecules, 2021
Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced.
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, José Pedraza-Chaverri   +3 more
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Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis [PDF]

Nucleic Acids Research, 2012
Mitochondrial ribosomes and translation factors co-purify with mitochondrial nucleoids of human cells, based on affinity protein purification of tagged mitochondrial DNA binding proteins. Among the most frequently identified proteins were ATAD3 and prohibitin, which have been identified previously as nucleoid components, using a variety of methods ...
He, J, Cooper, HM, Reyes, A, Di Re, M, Sembongi, H, Litwin, TR, Gao, J, Neuman, KC, Fearnley, IM, Spinazzola, A, Walker, JE, Holt, IJ   +11 more
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IRE1 KNOCKDOWN MODIFIES THE GLUTAMINE AND GLUCOSE DEPRIVATION EFFECT ON THE EXPRESSION OF NUCLEAR GENES ENCODING MITOCHONDRIAL PROTEINS IN U87 GLIOMA CELLS [PDF]

Biotechnologia Acta, 2016
We have studied the glucose and glutamine deprivation effect on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
O. O. , D. O. , D. O. , O.O. , O. H.
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Mitochondrial Quality Control Pathways Sense Mitochondrial Protein Import

Trends in Endocrinology & Metabolism, 2023
Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins, and the
Laurie P. Lee-Glover, Timothy E. Shutt
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The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses

Antioxidants, 2021
Horses have one of the highest skeletal muscle oxidative capacities amongst mammals, which, combined with a high glycolytic capacity, could perturb redox status during maximal exercise.
Marisa L. Henry, Deborah Velez-Irizarry, Joe D. Pagan, Lorraine Sordillo, Jeff Gandy, Stephanie J. Valberg   +5 more
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Restricted mitochondrial protein acetylation initiates mitochondrial autophagy [PDF]

Journal of Cell Science, 2013
As nutrient-sensing nuclear/cytosolic acetylation mediates cellular autophagy, we investigated whether mitochondrial acetylation modulates mitochondrial autophagy. Knockdown of GCN5L1, a component of the mitochondrial acetyltransferase machinery, diminished mitochondrial protein acetylation and augmented mitochondrial enrichment of autophagy mediators.
Bradley R, Webster, Iain, Scott, Kim, Han, Jian H, Li, Zhongping, Lu, Mark V, Stevens, Daniela, Malide, Yong, Chen, Leigh, Samsel, Patricia S, Connelly, Mathew P, Daniels, J Philip, McCoy, Christian A, Combs, Marjan, Gucek, Michael N, Sack   +14 more
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Mitochondrial protein dysfunction in pathogenesis of neurological diseases

Frontiers in Molecular Neuroscience, 2022
Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal ...
Liang Wang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Ziyun Yang, Xiumei He, Xiumei He, Xiumei He, Shiming Pu, Shiming Pu, Shiming Pu, Cheng Yang, Cheng Yang, Cheng Yang, Qiong Wu, Qiong Wu, Qiong Wu, Zuping Zhou, Zuping Zhou, Xiaobo Cen, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao, Hongxia Zhao   +23 more
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